Search Results - alfredo+quinones-hinojosa

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Nanoparticle Modification of Human Adipose-derived Mesenchymal Stem Cells for Brain Cancer and Other Neurological Diseases

Human Adipose-derived Mesenchymal Stem Cells can be engineered to synthesize and release anti-tumor proteins and therefore can be used as “Trojan Horses”. The inventors have created a novel technology which encompasses a solution containing biodegradable, polymeric nanoparticles that is combined with Freshly-extracted Adipose Tissue (F.A.T.) (from...

Published: 9/26/2024 | Inventor(s): Jordan Green, Alfredo Quinones-Hinojosa

Keywords(s): Biologics, Brain Cancer, Cancers, Cell Therapy, CNS and Neurological Disorders, Disease Indication, Drug Delivery Vehicle, Glioma, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Whole cell

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Glioma

Quantitative Tissue Property Mapping for Real-time Tumor Detection and Interventional Guidance

AbstractReal-Time, Interventional Guidance for Tumor Detection and ExcisionJHU REF: C12934 Invention Novelty: A novel optical method for the identification and differentiation of tumor versus non-tumor tissue with direct visual cue for use in real-time, continuous and noninvasive guidance for tumor excision. Value Proposition: Approximately 13,000 brain...

Published: 9/26/2024 | Inventor(s): Jiefeng Xi, Alfredo Quinones-Hinojosa, Elliott Mcveigh, Kaisorn Chaichana, Carmen Kut, Xingde Li

Keywords(s): Cancers, Disease Indication, Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Interventional and Surgical Systems, Optical Coherence Tomography (OCT), Surgical Navigation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Use of AGX/UAP Inhibitors to Inhibit Flux through the Hexosamine Biosynthetic Pathway (HBP)

Unmet Need: Greatly enhanced glucose metabolism – known as the Warburg effect – is a metabolic alteration that characterizes almost all types of cancer. Over 50 years of attempts to develop therapies that target the Warburg effect have failed, largely because of safety issues connected to interfering with central energy metabolism. There is a need for...

Published: 9/26/2024 | Inventor(s): Kevin Yarema, Christopher Saeui, Alfredo Quinones-Hinojosa, Sagar Shah

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Therapeutic Nanofiber Hydrogels for Local Treatment of Brain-related Diseases

We have developed a novel type of therapeutic agent-containing liquids that comprise self-assembling peptide nanofibers and physically encapsulated and chemically bound medicinal compounds, capable of transforming into a gel form upon contact with body fluids. The resulting gel can gradually release the incorporated therapeutic agents in a controlled...

Published: 9/26/2024 | Inventor(s): Honggang Cui, Alfredo Quinones-Hinojosa

Keywords(s): CNS and Neurological Disorders, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics, Topical Administration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Self-Assembling Verteporfin Amphiphiles (SAVA) for Local Cancer Therapy

Unmet Need: Brain tumors including aggressive Glioblastoma (GBM) remain a large societal burden due to the large number of affected patients and overall poor survival rates. A promising FDA-approved drug verteporfin (VP) was identified that directly targets transcription factors upregulated in GBM, but practical use of this drug to treat GBM is limited...

Published: 9/26/2024 | Inventor(s): Sagar Shah, Juan Carlos Martinez-Gutierrez, Alejandro Ruiz-Valls, Ran Lin, Honggang Cui, Alfredo Quinones-Hinojosa

Keywords(s): Brain Cancer, Cancers, Disease Indication, Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

NKCC1-pcDNA3-GFP

Invention novelty: This tangible material is a plasmid vector expressing a NKCC1-EGFP fusion protein. Value Proposition: NKCC1 (Na+-K+-Cl- cotransporter 1) regulates cell volume and accumulation of intracellular Cl- and has been shown to promote invasiveness of brain tumor cells by modulating cell adhesion and cell migration. This vector is a tool that...

Published: 9/26/2024 | Inventor(s): Tomas Garzon-Muvdi, Colette Aprhys, Alfredo Quinones-Hinojosa

Keywords(s): Basic Research Biomarker, Brain Cancer, Cancers, Cell Signaling, Cloning Reagents, Discovery/Research Tools, Disease Indication, Glioblastoma, Glioma, Molecular Switches/Receptors, Plasmid, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Brain Cancer