Search Results - sagar+shah

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Use of AGX/UAP Inhibitors to Inhibit Flux through the Hexosamine Biosynthetic Pathway (HBP)

Unmet Need: Greatly enhanced glucose metabolism – known as the Warburg effect – is a metabolic alteration that characterizes almost all types of cancer. Over 50 years of attempts to develop therapies that target the Warburg effect have failed, largely because of safety issues connected to interfering with central energy metabolism. There is a need for...

Published: 10/3/2024 | Inventor(s): Kevin Yarema, Christopher Saeui, Alfredo Quinones-Hinojosa, Sagar Shah

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Self-Assembling Verteporfin Amphiphiles (SAVA) for Local Cancer Therapy

Unmet Need: Brain tumors including aggressive Glioblastoma (GBM) remain a large societal burden due to the large number of affected patients and overall poor survival rates. A promising FDA-approved drug verteporfin (VP) was identified that directly targets transcription factors upregulated in GBM, but practical use of this drug to treat GBM is limited...

Published: 10/4/2024 | Inventor(s): Sagar Shah, Juan Carlos Martinez-Gutierrez, Alejandro Ruiz-Valls, Ran Lin, Honggang Cui, Alfredo Quinones-Hinojosa

Keywords(s): Brain Cancer, Cancers, Disease Indication, Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities