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Search Results - ran+lin
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Supramolecular Hydrogels Containing Angiotensin Receptor Blockers for Targeted Treatment of Diabetic Wounds
Unmet Need: Dysregulation in the renin-angiotensin system (RAS) has been increasingly implicated in abnormal diabetic wound healing. The effect of angiotensin receptor blockers in a wounded subject can be harmful during the early stages of wound healing; however, use of angiotensin receptor blockers during the later proliferative and remodeling stages...
Published: 3/13/2025
|
Inventor(s):
Honggang Cui
,
Jeremy Walston
,
Peter Abadir
,
Ran Lin
Keywords(s):
Drug Delivery Vehicle
,
Therapeutic Matter
,
Therapeutics
Category(s):
Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms
,
Technology Classifications > Therapeutic Modalities
Self-Assembling Verteporfin Amphiphiles (SAVA) for Local Cancer Therapy
Unmet Need: Brain tumors including aggressive Glioblastoma (GBM) remain a large societal burden due to the large number of affected patients and overall poor survival rates. A promising FDA-approved drug verteporfin (VP) was identified that directly targets transcription factors upregulated in GBM, but practical use of this drug to treat GBM is limited...
Published: 3/13/2025
|
Inventor(s):
Sagar Shah
,
Juan Carlos Martinez-Gutierrez
,
Alejandro Ruiz-Valls
,
Ran Lin
,
Honggang Cui
,
Alfredo Quinones-Hinojosa
Keywords(s):
Brain Cancer
,
Cancers
,
Disease Indication
,
Drug Delivery Vehicle
,
Hydrogel
,
Therapeutic Matter
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Neurology
,
Clinical and Disease Specializations > Oncology > Brain Cancer
,
Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Therapeutic Modalities
A p105-based NF-(kappa) B Super repressor
C04290: A p105-based NF-(kappa) B Super repressor Technical Details: Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, programmed cell death (apoptosis), and developmental processes. In normal cells, NF-kB is latent, and is activated transiently by stimuli and stresses. However, under pathological...
Published: 3/13/2025
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Inventor(s):
Li Lin
Keywords(s):
Biologics
,
Cancers
,
Chemotherapy
,
Disease Indication
,
Nucleic Acid
,
Single
,
Skin Cancer
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
,
Therapy Type
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Dermatology
,
Clinical and Disease Specializations > Oncology > Skin Cancer
,
Technology Classifications > Therapeutic Modalities > Gene Therapies
,
Technology Classifications > Therapeutic Modalities > Proteins
,
Technology Classifications > Therapeutic Modalities > Targets
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Therapeutic Modalities
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