Search Results - christopher+saeui

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A Platform to Improve Metabolic Glycoengineering in Biomanufacturing

Unmet Need: Methods to control glycosylation, a critical post-translational modification of therapeutic proteins, now focus on maintaining conventional glycosylation profiles. Strict adherence to naturally-occurring glycosylation patterns, however, hinders and in some cases precludes the development of novel protein therapeutics required for rare diseases...

Published: 3/14/2025 | Inventor(s): Kevin Yarema, Christian Agatemor, Christopher Saeui, Matthew Buettner, Jamie Spangler, Seth Ludwig, Zachary Bernstein, Kris Dammen-Brower, Riddhima Deenar Chitre

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Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Industrial Tech

Use of AGX/UAP Inhibitors to Inhibit Flux through the Hexosamine Biosynthetic Pathway (HBP)

Unmet Need: Greatly enhanced glucose metabolism – known as the Warburg effect – is a metabolic alteration that characterizes almost all types of cancer. Over 50 years of attempts to develop therapies that target the Warburg effect have failed, largely because of safety issues connected to interfering with central energy metabolism. There is a need for...

Published: 3/13/2025 | Inventor(s): Kevin Yarema, Christopher Saeui, Alfredo Quinones-Hinojosa, Sagar Shah

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities