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Search Results - seth+ludwig
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Multispecific Antibodies that Induce Downregulation of Programmed Death-ligand 1
Unmet Need: It is estimated that in 2018 there were more than 17 million new cases of cancer worldwide (see ACS). Immune checkpoint therapies have become a powerful treatment route for a wide variety of cancer types and have increased the life expectancy for patients whose disease is refractory to all other therapies. Due to variability in patient response...
Published: 3/14/2025
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Inventor(s):
Jamie Spangler
,
Seth Ludwig
,
Angela Zhu
,
Rakeeb Kureshi
,
Helen Dooley
Keywords(s):
Category(s):
Technology Classifications > Therapeutic Modalities
,
Technology Classifications > Therapeutic Modalities > Antibodies
Engineered Cytokine-antibody Fusion for Targeted Expansion of Immune Effector Cells
Unmet NeedGlobal revenue from the cytokine therapeutics market was valued at approximately $16.5 billion in 2018, and cytokine immunotherapy is a promising field of anti-cancer treatments for a broad range of cancer types. In particular, interleukin-2 (IL-2) therapy is shown to stimulate anti-cancer immunity. However, IL-2 activates contradictory immune...
Published: 3/14/2025
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Inventor(s):
Jamie Spangler
,
Jakub Tomala
,
Michael Leff
,
Seth Ludwig
,
Elissa Leonard
,
Marek Kovar
,
Jirina Kovarova
Keywords(s):
Biologics
,
Cancers
,
Disease Indication
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Technology Classifications > Therapeutic Modalities > Antibodies
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Therapeutic Modalities > Immunotherapies
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Technology Classifications > Therapeutic Modalities > Biologics
A Platform to Improve Metabolic Glycoengineering in Biomanufacturing
Unmet Need: Methods to control glycosylation, a critical post-translational modification of therapeutic proteins, now focus on maintaining conventional glycosylation profiles. Strict adherence to naturally-occurring glycosylation patterns, however, hinders and in some cases precludes the development of novel protein therapeutics required for rare diseases...
Published: 3/14/2025
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Inventor(s):
Kevin Yarema
,
Christian Agatemor
,
Christopher Saeui
,
Matthew Buettner
,
Jamie Spangler
,
Seth Ludwig
,
Zachary Bernstein
,
Kris Dammen-Brower
,
Riddhima Deenar Chitre
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Industrial Tech
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