Search Results - colette+aprhys

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NKCC1-pcDNA3-GFP

Invention novelty: This tangible material is a plasmid vector expressing a NKCC1-EGFP fusion protein. Value Proposition: NKCC1 (Na+-K+-Cl- cotransporter 1) regulates cell volume and accumulation of intracellular Cl- and has been shown to promote invasiveness of brain tumor cells by modulating cell adhesion and cell migration. This vector is a tool that...

Published: 3/13/2025 | Inventor(s): Tomas Garzon-Muvdi, Colette Aprhys, Alfredo Quinones-Hinojosa

Keywords(s): Basic Research Biomarker, Brain Cancer, Cancers, Cell Signaling, Cloning Reagents, Discovery/Research Tools, Disease Indication, Glioblastoma, Glioma, Molecular Switches/Receptors, Plasmid, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Brain Cancer

Novel Human Metastatic Breast Cancer Cell Line (RBC3)

C11928: Novel Human Metastatic Breast Cancer Cell Line (RBC3) Value Proposition: Johns Hopkins researchers developed a human breast cancer cell line (RBC3) to study spinal metastasis. Specifically, the cell line was isolated from a spinal metastatic lesion, and was tagged with GFP and luciferase. When RBC3 is injected into the left ventricle of athymic...

Published: 3/13/2025 | Inventor(s): Daniel Sciubba, Mari Groves, Colette Aprhys, Rachel Sarabia-Estrada, Patricia Zadnik

Keywords(s): Breast Cancer, Cancer Cells, Cancers, Cell Lines, Cell Model, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools