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Search Results - stem+cells
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SpinΩ – A Multi-well Bioreactor for Culturing 3D Organoids
UNMET NEEDSpinning bioreactors have been used for three-dimensional (3D) cell culture and generation of organ-like tissues (organoids). However, current spinning bioreactors available on the market (e.g. the Corning® disposable spinner flasks) have several major challenges including requiring a large volume of medium and incubator space, large sample-to-sample...
Published: 3/13/2025
|
Inventor(s):
Hongjun Song
,
Guo-li Ming
,
Mingxi Song
,
Christopher Hadiono
,
William Jeang
,
Ha Nam Nguyen
,
Xuyu Qian
Keywords(s):
Bioreactor-based Manufacturing
,
Cell Model
,
Discovery/Research Tools
,
In Vitro Research Tool
,
Industrial Manufacturing
,
Research Instrument
,
Stem Cells
Category(s):
Technology Classifications > Research Tools
,
Technology Classifications > Industrial Tech > Bioreactors
,
Technology Classifications > Industrial Tech > Industrial Manufacturing
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools >
Stem Cells
,
Technology Classifications > Industrial Tech
,
Technology Classifications > Engineering Tech > Bioreactors
,
Technology Classifications > Engineering Tech > Industrial Manufacturing
Functional Fibers for Ex Vivo Expansion of Stem and Progenitor Cells
NeedUmbilical cord blood is a promising alternative source of hematopoietic stem/progenitor cells (HSPCs) for allogeneic and autologous hematopoietic stem cell transplantation for the treatment of a variety of hematological disorders and as supportive therapy for malignant diseases. However, the low number of HSPCs obtainable from a single donor restricts...
Published: 3/13/2025
|
Inventor(s):
Kam Leong
,
Kian-Ngiap Chua
,
Seeram Ramakrishna
,
Hai-Quan Mao
Keywords(s):
Basic Research Biomarker
,
Cell Model
,
Discovery/Research Tools
,
In Vitro Research Tool
,
Stem Cells
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools >
Stem Cells
,
Technology Classifications > Research Tools
Induced Pluripotent Stem Cell Lines (BC1 and C7) and Plasmids (pEB-C5, pEB-Tg)
The Material consists of two induced pluripotent stem (iPS) cell lines derived from human bone marrow and cord blood.and plasmids used to create these virus-free and integration-free human iPS cell lines.
Published: 3/13/2025
|
Inventor(s):
Linzhao Cheng
Keywords(s):
Basic Research Biomarker
,
Cell Model
,
Cloning Reagents
,
Discovery/Research Tools
,
In Vitro Research Tool
,
Plasmid
,
Research Reagent
,
Stem Cells
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools >
Stem Cells
,
Technology Classifications > Research Tools > Vectors & Plasmids
,
Technology Classifications > Research Tools
Generation of heart field-specific progenitor cells from pluripotent
stem cells
Unmet Need:Heart disease, the number one killer, frequently occurs in a chamber-restricted fashion. While patient-derived pluripotent
stem cells
(iPSCs) offer unprecedented opportunities to treat and repair damaged hearts, iPSC-derived heart cells are highly heterogeneous, and it remains unknown if chamber-specific heart cells can be induced and isolated....
Published: 3/13/2025
|
Inventor(s):
Peter Andersen
,
Chulan Kwon
Keywords(s):
Cardiovascular Diseases
,
Cell Model
,
Discovery/Research Tools
,
Disease Indication
,
In Vitro Research Tool
,
Stem Cells
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Cardiovascular
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools >
Stem Cells
,
Technology Classifications > Research Tools
Cancer in Angiogenesis
Unmet NeedIn the United States alone, almost 8.5 million people suffer from peripheral artery disease (PAD). The market for PAD and Peripheral Vascular Disease (PVD) is expected to reach $378.53 million with a CAGR of 7.06% by 2024. Therapeutic angiogenesis are therapies aimed at growing new vessels into compromised tissue. Wound healing, PAD, and coronary...
Published: 3/13/2025
|
Inventor(s):
Andrew Schulick
Keywords(s):
Biologics
,
Cardiovascular Diseases
,
Cell Model
,
Coronary Heart Disease
,
Discovery/Research Tools
,
Disease Indication
,
In Vitro Research Tool
,
Peripheral Artery Disease
,
Stem Cells
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutic Substance Synthesis Method
,
Therapeutics
,
Whole cell
,
Wound Healing
Category(s):
Technology Classifications > Therapeutic Modalities >
Stem Cells
,
Clinical and Disease Specializations > Wound Healing
,
Clinical and Disease Specializations > Cardiovascular
,
Technology Classifications > Research Tools >
Stem Cells
KA.1;KA.3 (human keratinocyte-iPSC)
Technical Details: Described are induced pluripotent
stem cells
(iPSC) generated from keratinocytes. Keratinocytes were plucked and cultured from human hair and reprogrammed using non-viral, non-integrating methods. The resulting iPSCs contain no evidence of integrated pluripotency transgenes. Associated Publication: PLoS One. 2012;7(8):e42838.
Published: 3/13/2025
|
Inventor(s):
Elias Zambidis
Keywords(s):
Basic Research Biomarker
,
Cell Model
,
Discovery/Research Tools
,
In Vitro Research Tool
,
Stem Cells
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools >
Stem Cells
,
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Human Cell Lines
HDL2 iPSCs
Invention Novelty: Generation of three lines of induced pluripotent
stem cells
derived from fibroblast cell lines developed from patients with Huntington's disease-like 2.Value Proposition: HDL2, discovered and genetically defined by the Margolis group, is a rare, autosomal dominant neurodegenerative disorder, clinically and neuropathologically...
Published: 3/13/2025
|
Inventor(s):
Russell Margolis
,
Christopher Ross
,
Dobrila Rudnicki
,
Hongjun Song
,
Sergey Akimov
Keywords(s):
Cell Lines
,
Cell Model
,
CNS and Neurological Disorders
,
Discovery/Research Tools
,
Disease Indication
,
Human Cell Lines
,
Huntington's Disease
,
In Vitro Research Tool
,
Neurodegeneration
,
Stem Cells
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Neurology > Huntington's Disease
,
Clinical and Disease Specializations > Neurology > Neurodegeneration
,
Clinical and Disease Specializations > Rare Diseases
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Human Cell Lines
,
Technology Classifications > Research Tools >
Stem Cells
,
Clinical and Disease Specializations > Neurology
,
Technology Classifications > Research Tools
Generation of Adult Heart Muscle from Human Pluripotent
Stem Cells
Unmet Need:Pluripotent
stem cells
(PSCs) are capable of becoming all types of patients’ body cells and thus, provide unprecedented opportunities for disease modeling and personalized medicine. With the capability, current cardiac regenerative medicine focuses on utilizing PSCs for modeling heart disease and cell-based interventions of cardiac repair....
Published: 3/13/2025
|
Inventor(s):
Chulan Kwon
,
Gunsik Cho
Keywords(s):
Cardiovascular Diseases
,
Cell Model
,
Cell Therapy
,
Discovery/Research Tools
,
Disease Indication
,
In Vitro Research Tool
,
In Vivo Research Tool
,
Single
,
Stem Cells
,
Therapeutic Matter
,
Therapeutics
,
Therapy Type
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Cardiovascular
,
Technology Classifications > Research Tools
,
Technology Classifications > Therapeutic Modalities > Cell Therapies
,
Technology Classifications > Therapeutic Modalities
Three-dimensional Vascular Network Assembly from Diabetic Patient-derived Induced Pluripotent
Stem Cells
In diabetics, hyperglycemia results in deficient endothelial progenitors and cells, leading to cardiovascular complications. We aim to engineer three-dimensional (3D) vascular networks in synthetic hydrogels from type-1 diabetes (T1D) patient-derived human induced pluripotent
stem cells
(hiPSCs), thus serving as a transformative autologous vascular...
Published: 3/13/2025
|
Inventor(s):
Sharon Gerecht
,
Xin Yi Chan
,
Quinton Smith
,
Yu-I Shen
Keywords(s):
Biologics
,
Cell Model
,
Diabetes
,
Discovery/Research Tools
,
Disease Indication
,
In Vitro Research Tool
,
Metabolic Disorders
,
Stem Cells
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutic Substance Synthesis Method
,
Therapeutics
,
Translational Research Biomarker
,
Whole cell
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Diabetes
,
Clinical and Disease Specializations > Metabolic Diseases
,
Technology Classifications > Therapeutic Modalities
,
Technology Classifications > Therapeutic Modalities > Biologics
,
Technology Classifications > Therapeutic Modalities > Cell Therapies
,
Technology Classifications > Therapeutic Modalities >
Stem Cells
Multiple Lines of Induced Pluripotent
Stem Cells
(iPSCs) Derived from Members of an American Family with, and without DISC1 Mutations Associated with Schizophrenia and Depression
Invention Novelty: These tangible materials are induced Pluripotent
Stem Cells
(iPSCs) derived from members with or without DISC1 (Disrupted in schizophrenia 1) mutations in an American family associated with schizophrenia. Value Proposition:Mutations in DISC1 have been shown to predispose individuals to the development of psychiatric illnesses such...
Published: 3/13/2025
|
Inventor(s):
Hongjun Song
,
Christopher Ross
,
Guo-li Ming
,
Russell Margolis
Keywords(s):
Cell Model
,
CNS and Neurological Disorders
,
Discovery/Research Tools
,
Disease Indication
,
In Vitro Research Tool
,
Psychiatric Diseases
,
Schizophrenia
,
Stem Cells
,
Target-based Screening Tool
,
Translational Research Biomarker
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Psychiatry > Schizophrenia
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools >
Stem Cells
,
Technology Classifications > Diagnostics
,
Clinical and Disease Specializations > Psychiatry
,
Technology Classifications > Research Tools > Human Cell Lines
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