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Immortalization of Nociceptive Dorsal Root Ganglion Sensory Neurons

Unmet need This invention involves a novel method to immortalize Nociceptive dorsal root ganglion (DRG) neurons. DRG neurons are terminally differentiated cells that extend long axons to their target tissues. More than half of all DRG neurons are unmyelinated axons that extend to the skin and have nociceptive properties. In many studies on peripheral...

Published: 6/27/2024 | Inventor(s): Weiran Chen, Ahmet Hoke

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Ethoxyquin and Derivatives for Treatment of Peripheral Neuropathies and Other Neurodegenerative Disorders

Peripheral neuropathies are a group of neurodegenerative disorders affecting the peripheral nerves. Currently there is no effective therapy that prevents nerve degeneration except in cases of autoimmune peripheral neuropathies. Wehave now identified a compound, ethoxyquin (EQ), that prevents nerve degeneration in chemotherapy-induced peripheral neuropathy...

Published: 6/27/2024 | Inventor(s): Weiran Chen, Jing Zhu, Ahmet Hoke

Keywords(s): CNS and Neurological Disorders, Disease Indication, Neuropathy, Non-novel, Off-the-shelf, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities