Search Results - gabsang+lee

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Direct Derivation of Functional Schwann Cells from Human Pluripotent Stem Cells (hPSCs) as a Source for Cell-based Therapy to Schwann Cell-related Degenerative Diseases

Unmet NeedPermanent peripheral nerve damage can be caused by acute traumatic injury, or peripheral neuropathy may develop gradually, secondary to hereditary disorders (i.e. Charcot-Marie-Tooth), chronic diseases (i.e., diabetes) and aging-related demyelination symptoms. The prevalence of peripheral neuropathy may be as high as 39% among older adults...

Published: 9/27/2024 | Inventor(s): Gabsang Lee, Minseong Kim, Byoung Chol Oh

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Category(s): Technology Classifications > Therapeutic Modalities

Platform for drug screening in human neurons

Unmet NeedThe WHO has predicted that neurological disorders (NDs) will become the second leading cause of death in 20 years after cardiovascular diseases. Various proteins have been identified to aggregate and accumulate in the brain depending on the indication: amyloid-beta or tau in Alzheimer’s Disease, alpha-synuclein in Parkinson’s disease, and...

Published: 9/27/2024 | Inventor(s): Gabsang Lee, Minseong Kim, Eun Ra, Han Seok Ko, Xiaobo Mao

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Category(s): Clinical and Disease Specializations > Neurology > Parkinson’s Disease, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities

Pharmacological Intervention of the Arachidonic Acid Pathway to Cure Amyotrophic Lateral Sclerosis

Unmet NeedAmyotrophic Lateral Sclerosis (ALS) affects as many as 30,000 people in the United States alone, with 5,000 new cases diagnosed every year. ALS is a fatal neuromuscular disease that is characterized by a progressive degeneration of the motor nerve cells and spinal cord. There are only two drugs approved by FDA for the treatment of ALS, and...

Published: 9/27/2024 | Inventor(s): Gabsang Lee, Hyungjin Eoh, Hojae Lee, Thomas Lloyd, Nicholas Maragakis

Keywords(s): Amyotrophic Lateral Sclerosis, CNS and Neurological Disorders, Disease Indication, Natural compounds, Non-novel, Predicted Novelty, Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities > Repurposed Drugs

Human IPSC-Based Drug Testing Platform for Duchenne Muscular Dystrophy

Unmet NeedThe development of new drugs is a capital and time intensive process. For this reason, the development of orphan drugs for those diseases that affect a small subset of the population. One of such diseases, Duchenne’s muscular dystrophy (DMD) affects 1 in 5000 boys worldwide and has no known cure. Current drug screen platforms include animal...

Published: 9/27/2024 | Inventor(s): Gabsang Lee, Kathryn Wagner, Congshan (Sunny) Sun

Keywords(s): Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Muscular Disorders, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Research Tools > Research Stem Cells