Search Results - muscular+disorders

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Human IPSC-Based Drug Testing Platform for Duchenne Muscular Dystrophy

Unmet NeedThe development of new drugs is a capital and time intensive process. For this reason, the development of orphan drugs for those diseases that affect a small subset of the population. One of such diseases, Duchenne’s muscular dystrophy (DMD) affects 1 in 5000 boys worldwide and has no known cure. Current drug screen platforms include animal...

Published: 3/14/2025 | Inventor(s): Gabsang Lee, Kathryn Wagner, Congshan (Sunny) Sun

Keywords(s): Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Muscular Disorders, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Research Tools > Research Stem Cells

Soluble Form of Activin Type IIB Receptor (ACVR2B/Fc)

Invention Novelty: This technology identifies the use of soluble receptor (ACVR2B/Fc) to block the activities of members of the TGF-beta superfamily of signaling molecules.Value Proposition:Myostatin is a member of the TGF-β family; it suppresses muscle growth and its absence stimulates muscle growth substantially. Most of the myostatin inhibitors...

Published: 3/13/2025 | Inventor(s): Se-Jin Lee

Keywords(s): Biologics, Disease Indication, Muscular Disorders, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities

Rabbit Serum 5690

C10529: Rabbit Serum 5690: Antibodies Against Rat Lmo7Value Proposition: • Polyclonal antibodies against rat Lmo7Technical Details: Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins. The nuclear lamina...

Published: 3/13/2025 | Inventor(s): Katherine Wilson

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Genetic Disorders, Muscular Disorders, Peptides, Polyclonal Antibodies, Proteomics/Immunoassays, Proteomics/Immunoassays Antiserum, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Musculoskeletal

C05182: Novel Protein Increases Muscle Mass

Technical Details: Muscle mass is normally regulated by the activities of members of the transforming growth factor-B (TGF-B) superfamily, which act to limit muscle growth. Scientists at JHU have now found a protein that is capable of binding certain members of the TGF-B family and inhibiting their activities in vitro. Therefore this protein has important...

Published: 3/13/2025 | Inventor(s): Se-Jin Lee

Keywords(s): Biologics, Disease Indication, Muscular Disorders, Protein, Single, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type