Search Results - se-jin+lee

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Invention Novelty: The Johns Hopkins researchers have developed BTKO mice having floxed alleles for both Bmp1 and Tll1, such that they can be conditionally knocked out either temporally, postnatally, or in a tissue-specific, non-lethal manner and have overcome issues of functional redundancy. Value Proposition: Osteogenesis imperfecta (OI), or brittle...

Published: 3/13/2025 | Inventor(s): Se-Jin Lee

Keywords(s): Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Skeletal Disorders, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

GDF11 Flox Mouse Line

Brief OverviewJHU researchers generated the GDF11 flox mouse line by inserting a loxP site upstream of exon 2 and a floxed neo cassette downstream of exon 3. Cre mediated recombination was then used to remove the neo cassette leaving exons 2 and 3 floxed (Molecular Image Detail). Detailed Technology OverviewMyostatin (Mstn) and growth/differentiation...

Published: 3/13/2025 | Inventor(s): Se-Jin Lee

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

TII2 Flox Mouse Line

ABSTRACTJHU researcher generated mice carrying a targeted deletion of the Tll2 gene. The construct was generated which a LoxP site and a LoxP/neo cassette which were introduced into introns 6 and 7, respectively. Following homologous recombination in embryonic stem cells and transfer of the targeted cells into blastocysts, several chimeric mice were...

Published: 3/13/2025 | Inventor(s): Se-Jin Lee

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Cell Lines, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

TII1 Flox Mouse Line

ABSTRACTThis genetically engineered mouse line carries a floxed allele for TII1, which encodes a metalloprotease involved in regulating myostatin and GDF-11 activity. The line may be useful for developing drugs capable of modulating the activities of myostatin and/or GDF-11, for example for enhancing muscle growth and regeneration. TII1 is also involved...

Published: 3/13/2025 | Inventor(s): Se-Jin Lee

Keywords(s): Basic Research Biomarker, Cell Lines, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Bmp1 Flox Mouse Line

ABSTRACTThis genetically engineered mouse line carries a floxed allele for Bmpl, which encodes a metalloprotease involved in regulating myostatin and GDF-11 activity. The line may be useful for developing drugs capable of modulating the activities of myostatin and/or GDF-11, for example for enhancing muscle growth and regeneration. Bmp1 is also involved...

Published: 3/13/2025 | Inventor(s): Se-Jin Lee

Keywords(s): Assay, Basic Research Biomarker, Cell Lines, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays

Soluble Form of Activin Type IIB Receptor (ACVR2B/Fc)

Invention Novelty: This technology identifies the use of soluble receptor (ACVR2B/Fc) to block the activities of members of the TGF-beta superfamily of signaling molecules.Value Proposition:Myostatin is a member of the TGF-β family; it suppresses muscle growth and its absence stimulates muscle growth substantially. Most of the myostatin inhibitors...

Published: 3/13/2025 | Inventor(s): Se-Jin Lee

Keywords(s): Biologics, Disease Indication, Muscular Disorders, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities

C05182: Novel Protein Increases Muscle Mass

Technical Details: Muscle mass is normally regulated by the activities of members of the transforming growth factor-B (TGF-B) superfamily, which act to limit muscle growth. Scientists at JHU have now found a protein that is capable of binding certain members of the TGF-B family and inhibiting their activities in vitro. Therefore this protein has important...

Published: 3/13/2025 | Inventor(s): Se-Jin Lee

Keywords(s): Biologics, Disease Indication, Muscular Disorders, Protein, Single, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type