Search Results - elias+zambidis

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Clinical-Grade Therapeutic Progenitors Generated from Universal Donor Tankyrase/PARP-Inhibited Pluripotent Stem Cell Banks

Unmet Need / Invention Novelty: Regenerative cell therapies with conventional, lineage-primed human induced pluripotent stem cells (hiPSC) are limited by variable differentiation efficiency and poor in vivo functionality. There is an unmet need to establish novel methods for efficiently generating functional and transplantable therapeutic progenitors. Technical...

Published: 9/27/2024 | Inventor(s): Elias Zambidis, Ludovic Zimmerlin

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Research Stem Cells

Vascular Progenitors Generated from Tankyrase Inhibitor-Regulated Naïve Diabetic Human iPSC Potentiate Efficient Revascularization of Ischemic Retina

Unmet NeedIn the United States, approximately 14.6 million Americans are estimated to suffer from diabetic retinopathy by the year 2050 (see CDC). Diabetic retinopathy is a debilitating condition defined by the loss of vision due to leaky blood vessels of the retina. The current standard of care includes prevention measures, pharmacological therapies,...

Published: 9/27/2024 | Inventor(s): Elias Zambidis, Tea Soon Park

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Ophthalmology > Retinal Ischemia

KA.1;KA.3 (human keratinocyte-iPSC)

Technical Details: Described are induced pluripotent stem cells (iPSC) generated from keratinocytes. Keratinocytes were plucked and cultured from human hair and reprogrammed using non-viral, non-integrating methods. The resulting iPSCs contain no evidence of integrated pluripotency transgenes. Associated Publication: PLoS One. 2012;7(8):e42838.

Published: 9/26/2024 | Inventor(s): Elias Zambidis

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Stem Cells

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

CD34-CB-iPSC Lines (lines 6.2, 19.11)

C11071: High Quality Human Pluripotent Stem Cell (iPSC) LinesValue Proposition: - High quality, clinically safe iPSCs that are more akin to hESC - 300 times more efficient for human cell types - Molecular signatures that are highly similar to hESC - Differentiate robustly to vascular, hematopoietic, neural, and cardiac lineages - Cell lines that lack...

Published: 9/26/2024 | Inventor(s): Elias Zambidis

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Stem Cells