Search Results - drug+delivery+vehicle+synthesis+method

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Inhalable Supramolecular Therapeutics to Treat Lung Diseases

Unmet NeedThe current global market for respiratory drugs is expected to increase from $30.9 billion in 2016 to $41.3 billion in 2023. While many aerosol therapeutics are used to treat lung diseases such as chronic obstructive pulmonary disease, asthma, and cystic fibrosis, administration of drugs selectively to the lungs remains challenging. The nature...

Published: 6/28/2024 | Inventor(s): Honggang Cui, Caleb Anderson

Keywords(s): Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Lung Disorders, Polymers, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Compositions and Method for Production of Size-Controlled Ternary Nanoparticles for Sustained Release of Peptide Therapeutics

Unmet NeedType 2 diabetes (T2D) contributes to 90% of all cases of diabetes and represents a critical global public health problem. T2D specifically affects glucose metabolism and those with the disease either do not produce enough insulin or do not respond properly to insulin signaling to maintain normal levels of glucose in the blood. Several serious...

Published: 6/28/2024 | Inventor(s): Hai-Quan Mao, Zhiyu He, Yizong Hu, Yongming Chen, Lixin Liu

Keywords(s): Biologics, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Compositionally Defined Plasmid DNA/Polycation Nanoparticles and Methods for Making the Same

Unmet NeedGene therapy can be a cure-all for genetic disorders, and can be a promising therapy for diseases such as cancer, neurodegenerative diseases, neurological disorders, heart disease or diabetes. The success of gene therapy is dependent on the safety, efficacy, and specificity of the treatment. The delivery vehicle, also known as a vector, is...

Published: 6/28/2024 | Inventor(s): Hai-Quan Mao, Yizong Hu, Martin Pomper, Heng-wen Liu, Il Minn, Christopher Ullman, Christine Carrington

Keywords(s): Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Therapeutic Modalities > Gene Therapies, Clinical and Disease Specializations > Oncology

Adhesive/adsorption switch on nanoparticles to increase tumor uptake and delay tumor clearance

Unmet NeedEffective drug delivery to solid tumors remains challenging. Outcome failure rates can reach 90% for current therapeutic approaches for solid tumors. The use of nanoparticles for the delivery of therapeutic agents can enhance the safety, pharmacokinetic profile, and bioavailability of administered drugs, leading to improved therapeutic tolerance...

Published: 6/27/2024 | Inventor(s): Stavroula Sofou, Sarah Stras, Alaina Howe, Aprameya Ganesh Prasad, Dominick Salerno

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Polymeric Nanoparticle Compositions for Encapsulation and Sustained Release of Protein Therapeutics and Methods for Scalable Production of the Same

Unmet NeedProtein therapeutics are used for a variety of medical treatments, such as cancer, infectious disease, hemophilia, anima, etc. The global market for protein drugs reached $174.7 billion in 2015. Therapeutic proteins support targeted therapeutic processes by compensating the deficiency of an essential protein. To successfully administer protein...

Published: 6/27/2024 | Inventor(s): Hai-Quan Mao, Sashank Reddy, Xiyu Ke, Chenhu Qiu, Daniel Lucena Domingues, Gregory Howard

Keywords(s): Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Biomimetic Anisotropic Polymeric Particles with Naturally Derived Cell Membranes for Enhanced Drug Delivery

Unmet Need: Although biomimetic polymeric particles have been used for drug delivery, these particles have not been able to mimic the natural cell in terms of size, shape, mechanical properties, and surface features. This invention is a biomimetic particle platform that can be used to simulate natural cells found throughout the body. Technology Overview:...

Published: 6/27/2024 | Inventor(s): Jordan Green, Randall Meyer, Elana Ben-Akiva

Keywords(s): Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics, Vesicle

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Synthesis of poly(β-amino ester)-co-polyethylene glycol (PEG-PBAE-PEG) polymer for gene and drug delivery

Non-viral vectors are widely investigated due to their ability to safely and effectively deliver exogenous genes and potentially cure diseases of genetic origin. Much portion of the ongoing research in the field is also dedicated to further optimize the existing vectors for in vivo applications. This work describes new compositions of matter of polyethylene...

Published: 6/27/2024 | Inventor(s): Jordan Green, Jayoung Kim, Stephany Tzeng

Keywords(s): Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Polymers, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Engineering Synthetic Brain Penetrating Gene Vectors

Unmet Need:Gene delivery to the central nervous system (CNS) has potential as a means for treating numerous debilitating neurological diseases. Viral gene delivery, though relatively efficient, has been limited by immunogenicity, low packaging capacity and difficulties in manufacture and scale-up. Non-viral gene vectors offer an attractive alternate...

Published: 6/27/2024 | Inventor(s): Graeme Woodworth, Clark Zhang, Panagiotis Mastorakos, Jung Soo Suk, Justin Hanes

Keywords(s): Drug Delivery Vehicle Synthesis Method, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

A Process for Making Iron Oxide Nanoparticle Preparations for Cancer Hyperthermia

C11199: Targeted radiation- and chemo-enhancing heat therapy for cancerNovelty: The proposed technology is a device and platform for treating local and metastatic cancer using multifunctionalized iron oxide nanoparticles in conjunction with radiation and chemotherapeutic agents.Value Proposition: Metastatic cancer is persistent and difficult to treat,...

Published: 6/27/2024 | Inventor(s): Zhigang Shen, Sung Lai Yun, Yit Wooi Goh, Meng Tack Ng, Robert Ivkov

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Improved Obligate Heterodimer FokI Cleavage Domain Variants for Creating Designed Zinc Finger Nucleases with Minimal Cytotoxicity

C11129: Site-specific and Permanent Modification of Genomes with Reduced CytotoxicityNovelty: This technology comprises the generation of re-engineered obligate heterodimer FokI nuclease domain variants to create ZFNs with minimal cell toxicity for targeted modifications in plant, mammalian and even human genomes.Value Proposition: Zinc finger nucleases...

Published: 6/27/2024 | Inventor(s): Sivaprakash Ramalingam, Karthikeyan Kandavelou, Srinivasan Chandrasegaran

Keywords(s): Drug Delivery Vehicle Synthesis Method, Gene Therapy, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities