Search Results - lung+disorders

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Inhalable Supramolecular Therapeutics to Treat Lung Diseases

Unmet NeedThe current global market for respiratory drugs is expected to increase from $30.9 billion in 2016 to $41.3 billion in 2023. While many aerosol therapeutics are used to treat lung diseases such as chronic obstructive pulmonary disease, asthma, and cystic fibrosis, administration of drugs selectively to the lungs remains challenging. The nature...

Published: 6/28/2024 | Inventor(s): Honggang Cui, Caleb Anderson

Keywords(s): Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Lung Disorders, Polymers, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Protection of lung cells from cigarette smoke, a primary insult causing chronic obstructive pulmonary disease (COPD) and other lung diseases, and ability to increase airway surface hydration and maintain ciliary function.

Unmet NeedChronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death globally by 2030, with cigarette smoke being a major cause. Despite the prevalence of COPD there has been very little progress in developing therapeutic strategy in past 20 years. Thus, mechanistic studies for therapeutic targets for treating...

Published: 6/27/2024 | Inventor(s): Douglas Robinson, Corrine Kliment, Venkataramana Sidhaye, Jennifer Nguyen

Keywords(s): Chronic Obstructive Pulmonary Disorder, Chronic Obstructive Pulmonary Disorder (COPD), Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Lung Disorders

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Respiratory Diseases > Chronic Obstructive Pulmonary Disorder

Handheld Emergency Cricothyrotomy Assist Device (Trade Name CricSpike™ )

Unmet need: The technology is an emergency airway device. Technology Overview: This technology is a handheld cricothyotomy assist device that ensures breathing tube placement into the trachea, reducing the risk of accidental placement into the surrounding tissue or puncture into the esophagus. The device can also function as a self-contained breathing...

Published: 6/27/2024 | Inventor(s): Antonio Spina, Steven Tropello, Michael Good, Travis Wallace, Qiuyin Ren, Ryan Walter, Himanshu Dashora, Sondra Rahmeh, Ronak Mehta, Jordan Kreger

Keywords(s): Carriers/Appliers, Disease Indication, Interventional and Surgical Systems, Lung Disorders, Surgical Instruments

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices

Therapies to Accelerate Resolution of Acute Lung Inflammation

Acute respiratory distress syndrome (ARDS) is a devastating inflammatory lung disease for which there are no effective targeted therapies. In experimental models of acute lung inflammation and injury, regulatory T cells (Tregs) orchestrate a pro-repair program; Tregs themselves are highly dependent on epigenetic mechanisms such as DNA hypomethylation. ...

Published: 6/27/2024 | Inventor(s): Franco D'alessio, Landon King, Benjamin Singer, Neil Aggarwal

Keywords(s): Acute Respiratory Distress Syndrome, Acute Respiratory Distress Syndrome (ARDS), Antagonists/Inhibitors, Chemotherapy, Disease Indication, Immunotherapy, Lung Disorders, Non-novel, Predicted Novelty, Repurposed, Single, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases > Acute Respiratory Distress Syndrome, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Repurposed Drugs

Circulating Pulmonary Hypertension Biomarker

UNMET NEEDPulmonary hypertension (PH) can result from a number of changes in the cardiorespiratory system that cause increased pulmonary arterial pressure. Hemodynamic evaluation is one of the best diagnostics, but pulmonary artery catheterization is expensive and invasive; therefore biomarkers that diagnosis and/or predict PH are needed. Some of...

Published: 6/27/2024 | Inventor(s): Jun Yang, Allen Everett

Keywords(s): Biomarker, Cardiovascular Diseases, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, Hypertension, In Vitro Diagnostics, Lung Disorders, Pulmonary Hypertension

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Hypertension, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Diagnostics

Histamine Releasing Factor (HRF) Inducible Mice

C12573: Transgenic HFR Mouse Model for Asthma and Allergy Drug DiscoveryNovelty: A mouse strain harboring lung epithelial cell-targeted inducible HRF, permitting the site-specific, regulatable HRF over-expression to study its use as a drug target for asthma and allergies.Value Proposition: Asthma is a prevalent chronic lung disorder characterized by...

Published: 6/27/2024 | Inventor(s): Susan MacDonald

Keywords(s): Asthma, Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock In Mouse Model, Lung Disorders, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Respiratory Diseases > Asthma, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Respiratory Diseases

TGFbeta Antagonists, Including AT1 Receptor Blockers, Rescue the Multisystem Pathogenesis of Marfan Syndrome

Unmet Need: Marfan syndrome is a disorder of the body's connective tissues. One out of every 5,000 people in the world has Marfan syndrome, or a related connective tissue disorder. Features of the disease include, emphysema (which frequently results in spontaneous lung rupture), eye problems, skeletal abnormalities, heart valve and aortic problems...

Published: 6/27/2024 | Inventor(s): Enid Neptune, Jennifer Habashi, Daniel Judge, Ronald Cohn, Harry Dietz

Keywords(s): Antibodies, Biologics, Disease Indication, Emphysema, Lung Disorders, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases > Emphysema, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities

HIMF and related proteins in pulmonary, cardiac and inflammatory disorders

C04858: HIMF and Related Proteins in Pulmonary, Cardiac and Inflammatory Disorders Technical Details: Hypoxia-Induced Mitogenic Factor (HIMF; also known as FIZZ1/RELM) a member of the resistin protein family, is a secreted protein that was found to be highly up regulated in the lungs as a result of hypoxia-induced pulmonary hypertension. HIMF has pro-mitogenic,...

Published: 6/27/2024 | Inventor(s): Hunter Champion, Qingning Su, Roger Johns

Keywords(s): Biomarker, Cardiovascular Diseases, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Inflammatory Disorders, Lung Disorders, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Hypoxia-induced Mitogenic Factor

C04061: Hypoxia-induced Mitogenic FactorValue Proposition: Johns Hopkins University is seeking licensees for Hypoxia-Induced Mitogenic Factor (HIMF/ FIZZ1/RELM), a cell line expressing tagged HIMF, antibodies to HIMF and receptor. HIMF provides a wide array of novel biomarkers and therapeutic targets for lung, vascular, cardiac and inflammatory diseases,...

Published: 6/27/2024 | Inventor(s): Xingwu Teng, Dechun Li, Roger Johns

Keywords(s): Biomarker, Cardiovascular Diseases, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, Hypertension, In Vitro Diagnostics, Inflammatory Disorders, Lung Disorders