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TGFbeta Antagonists, Including AT1 Receptor Blockers, Rescue the Multisystem Pathogenesis of Marfan Syndrome

Unmet Need: Marfan syndrome is a disorder of the body's connective tissues. One out of every 5,000 people in the world has Marfan syndrome, or a related connective tissue disorder. Features of the disease include, emphysema (which frequently results in spontaneous lung rupture), eye problems, skeletal abnormalities, heart valve and aortic problems...

Published: 3/13/2025 | Inventor(s): Enid Neptune, Jennifer Habashi, Daniel Judge, Ronald Cohn, Harry Dietz

Keywords(s): Antibodies, Biologics, Disease Indication, Emphysema, Lung Disorders, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases > Emphysema, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities