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Search Results - harry+dietz
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Treatment of fibrosis-associated pathologies through downstream TGF-β pathway inhibition
Value PropositionInhibits downstream signaling pathway of TGF-β signaling, reducing pleiotropic and off-target effects.Selectively targets tissue specific calpains, increasing efficacy as compared to current TGF-β signaling pathway inhibitory methods.Applicable to several disease models with specific focus on epithelial-to-mesenchymal transition pathologies....
Published: 3/13/2025
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Inventor(s):
David Kim
,
Harry Dietz
Keywords(s):
Biomarker
,
Cancers
,
Clinical Diagnostics
,
Disease Indication
,
Fibrosis Disorders
,
In Vitro Diagnostics
,
Mechanism-of-action Biomarker
,
Therapeutic Matter
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Fibrosis
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Therapeutic Modalities > Targets
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics
,
Technology Classifications > Therapeutic Modalities
Col3a1G209S heterozygous mice
Unmet Need:Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic connective tissue disorder. Patients with vEDS present with thin, translucent skin, easy bruising, and a characteristic facial appearance. Most critically, they are at risk for spontaneous rupture of the major arteries, hollow organs, and gravid uterus. Preclinical investigation of...
Published: 3/14/2025
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Inventor(s):
Harry Dietz
,
Caitlin Bowen
,
Juan Calderon Giadrosic
,
Mark Helmers
Keywords(s):
Category(s):
Clinical and Disease Specializations > Genetic Diseases
,
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Animal Models
Col3a1G938D heterozygous mice
Unmet Need:Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic connective tissue disorder. Patients with vEDS present with thin, translucent skin, easy bruising, and a characteristic facial appearance. Most critically, they are at risk for spontaneous rupture of the major arteries, hollow organs, and gravid uterus. Preclinical investigation of...
Published: 3/14/2025
|
Inventor(s):
Harry Dietz
,
Caitlin Bowen
Keywords(s):
Category(s):
Clinical and Disease Specializations > Genetic Diseases
,
Technology Classifications
,
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Animal Models
Loeys-Dietz Syndrome (LDS) Mouse Strains (Tgfbr2G357W/+ and Tgfbr1M318R/+)
Unmet Need:Loeys-Dietz Syndrome (LDS) is a rare genetic connective tissue disorder that is characterized by a high risk for aneurysm and dissection throughout the arterial tree and phenotypically resembles Marfan Syndrome. Marfan Syndrome and related disorders, such as LDS, have an incidence of 1 in 3000 to 5000 individuals (see UpToDate). LDS is specifically...
Published: 3/14/2025
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Inventor(s):
Harry Dietz
,
Elena MacFarlane
,
David Loch
Keywords(s):
Category(s):
Clinical and Disease Specializations > Genetic Diseases
,
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Animal Models
Targeted Epigenetic Therapy against Distal Regulatory Element of TGFB2 Expression for Scleroderma and Fibrotic Disease
Unmet NeedScleroderma disorders comprise a heterogeneous group of conditions linked by the presence of thickened, sclerotic skin lesions. These conditions result in a poor quality of life and have a poor prognostic outcome. In particular, systemic sclerosis (SSc) has a 10 year mortality rate of approximately 30%. However, the pathogenic mechanisms of...
Published: 3/13/2025
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Inventor(s):
Harry Dietz
,
Joseph Shin
Keywords(s):
Biomarker
,
Clinical Diagnostics
,
Diagnostic Biomarker
,
Disease Indication
,
Fibrosis Disorders
,
In Vitro Diagnostics
,
Prognostic Biomarker
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Fibrosis
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > Diagnostic Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Technology Classifications > Therapeutic Modalities
,
Technology Classifications > Diagnostics
Conditional mouse model of pseudoxanthoma elasticum (PXE); floxed Abcc6 allele
TITLE: Conditional mouse model of pseudoxanthoma elasticum (PXE); floxed Abcc6 alleleCASE NUMBER: C13613 ABSTRACTUsing ES-cells, JHU researchers generated a PXE conditional mouse model (floxed Abcc6 allele). When bred to a CMV-cre mouse, this mouse develops robust calcification in the vibrissae (snout of the mouse). They use this mouse model to test...
Published: 3/13/2025
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Inventor(s):
Harry Dietz
,
Shira Ziegler
Keywords(s):
Basic Research Biomarker
,
Cardiovascular Diseases
,
Cell Lines
,
Discovery/Research Tools
,
Disease Indication
,
In Vitro Research Tool
,
In Vivo Research Tool
,
Knock In Mouse Model
,
Mouse Cell Lines
,
Mouse Model
Category(s):
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools
,
Clinical and Disease Specializations > Cardiovascular
Fibrillin 1 Mutant Mice (W1572C Mutant Strain) and (D1545E Mutant Strain)
TITLE: Fibrillin 1 Mutant Mice (W1572C Mutant strain) and (D1545E Mutant Strain)CASE NUMBER: C13499ABSTRACTFibrillin1 D1545E Mutant StrainThese mice carry a D1545E mutation in the mouse Fbn1 gene and serve as a model of human stiff skin syndrome with increased collagen deposition in the dermis, decreased subcutaneous fat, and circulating anti-nuclear...
Published: 3/13/2025
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Inventor(s):
Harry Dietz
,
Elizabeth Gerber
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Discovery/Research Tools
,
Disease Indication
,
In Vitro Research Tool
,
In Vivo Research Tool
,
Knock In Mouse Model
,
Mouse Cell Lines
,
Mouse Model
,
Skin Disorders
,
Translational Research Biomarker
Category(s):
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools
,
Clinical and Disease Specializations > Dermatology
A Ketogenic Diet Rescues Neurogenesis Defects in a Mouse Model of Kabuki Syndrome
TITLE: A Ketogenic Diet Rescues Neurogenesis Defects in a Mouse Model of Kabuki SyndromeCASE NUMBER: C13532UNMET NEEDKabuki syndrome (KS) is a rare genetic disease resulting in intellectual disability, seen in association with postnatal growth retardation, immunological dysfunction and characteristic facial features. Currently, there are...
Published: 3/13/2025
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Inventor(s):
Hans Bjornsson
,
Joel Benjamin
,
Harry Dietz
Keywords(s):
Discovery/Research Tools
,
In Vivo Research Tool
,
Mouse Model
Category(s):
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools
Histone Reporter Alleles: Tools for in vitro and in vivo Epigenetic Therapeutic Development - Treatment Method
METHODS FOR TREATING MENDELIAN DISORDERS OF THE EPIGENETICMACHINERYJHU REF: C13083Invention novelty: A genetically encoded histone reporter allele system which can be utilized for high throughput screening in in vitro cellular systems.Value Proposition: Epigenetic modifications are thought to be one of the critical mechanisms that mediate gene-environment...
Published: 3/13/2025
|
Inventor(s):
Harry Dietz
,
Hans Bjornsson
Keywords(s):
Basic Research Biomarker
,
Biomarker
,
Clinical Diagnostics
,
Discovery/Research Tools
,
Disease Indication
,
Epigenetic
,
Genetic Disorders
,
In Vitro Diagnostics (Old)
,
In Vitro Research Tool
,
In Vivo Research Tool
,
Mouse Model
,
Mouse Model Xenograft
,
Target-based Screening Tool
Category(s):
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Assays
,
Clinical and Disease Specializations > Genetic Diseases
,
Technology Classifications > Diagnostics > Biomarkers
Enabling technology for epigenetic drug development
Invention novelty: This invention describes an improved histone reporter system that enables epigenetic therapeutic development in cell-based assays and potential therapeutic monitoring in animal models.Value PropositionIt is now widely appreciated that most human diseases are contributed by interplay of genetic and epigenetic factors. Understanding...
Published: 3/13/2025
|
Inventor(s):
Harry Dietz
,
Hans Bjornsson
Keywords(s):
Basic Research Biomarker
,
Biomarker
,
Clinical Diagnostics
,
Cloning Reagents
,
Discovery/Research Tools
,
Epigenetic
,
In Vitro Diagnostics
,
In Vitro Diagnostics (Old)
,
In Vitro Research Tool
,
Nucleotide
,
Research Reagent
,
Target-based Screening Tool
Category(s):
Technology Classifications > Research Tools > Nucleic Acids
,
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Assays
,
Technology Classifications > Diagnostics > Biomarkers
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