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Search Results - hans+bjornsson
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A Ketogenic Diet Rescues Neurogenesis Defects in a Mouse Model of Kabuki Syndrome
TITLE: A Ketogenic Diet Rescues Neurogenesis Defects in a Mouse Model of Kabuki SyndromeCASE NUMBER: C13532UNMET NEEDKabuki syndrome (KS) is a rare genetic disease resulting in intellectual disability, seen in association with postnatal growth retardation, immunological dysfunction and characteristic facial features. Currently, there are...
Published: 3/13/2025
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Inventor(s):
Hans Bjornsson
,
Joel Benjamin
,
Harry Dietz
Keywords(s):
Discovery/Research Tools
,
In Vivo Research Tool
,
Mouse Model
Category(s):
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools
Histone Reporter Alleles: Tools for in vitro and in vivo Epigenetic Therapeutic Development - Treatment Method
METHODS FOR TREATING MENDELIAN DISORDERS OF THE EPIGENETICMACHINERYJHU REF: C13083Invention novelty: A genetically encoded histone reporter allele system which can be utilized for high throughput screening in in vitro cellular systems.Value Proposition: Epigenetic modifications are thought to be one of the critical mechanisms that mediate gene-environment...
Published: 3/13/2025
|
Inventor(s):
Harry Dietz
,
Hans Bjornsson
Keywords(s):
Basic Research Biomarker
,
Biomarker
,
Clinical Diagnostics
,
Discovery/Research Tools
,
Disease Indication
,
Epigenetic
,
Genetic Disorders
,
In Vitro Diagnostics (Old)
,
In Vitro Research Tool
,
In Vivo Research Tool
,
Mouse Model
,
Mouse Model Xenograft
,
Target-based Screening Tool
Category(s):
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Assays
,
Clinical and Disease Specializations > Genetic Diseases
,
Technology Classifications > Diagnostics > Biomarkers
Enabling technology for epigenetic drug development
Invention novelty: This invention describes an improved histone reporter system that enables epigenetic therapeutic development in cell-based assays and potential therapeutic monitoring in animal models.Value PropositionIt is now widely appreciated that most human diseases are contributed by interplay of genetic and epigenetic factors. Understanding...
Published: 3/13/2025
|
Inventor(s):
Harry Dietz
,
Hans Bjornsson
Keywords(s):
Basic Research Biomarker
,
Biomarker
,
Clinical Diagnostics
,
Cloning Reagents
,
Discovery/Research Tools
,
Epigenetic
,
In Vitro Diagnostics
,
In Vitro Diagnostics (Old)
,
In Vitro Research Tool
,
Nucleotide
,
Research Reagent
,
Target-based Screening Tool
Category(s):
Technology Classifications > Research Tools > Nucleic Acids
,
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Assays
,
Technology Classifications > Diagnostics > Biomarkers
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