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Conditional mouse model of pseudoxanthoma elasticum (PXE); floxed Abcc6 allele

ABSTRACTUsing ES-cells, JHU researchers generated a PXE conditional mouse model (floxed Abcc6 allele). When bred to a CMV-cre mouse, this mouse develops robust calcification in the vibrissae (snout of the mouse). They use this mouse model to test drugs that will inhibit calcification in vivo. While PXE is a rare genetic condition, the researchers believe...

Published: 6/12/2026 | Inventor(s): Harry Dietz, Shira Ziegler

Keywords(s): Basic Research Biomarker, Cardiovascular Diseases, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Cell Lines, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Cardiovascular