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Conditional mouse model of pseudoxanthoma elasticum (PXE); floxed Abcc6 allele

TITLE: Conditional mouse model of pseudoxanthoma elasticum (PXE); floxed Abcc6 alleleCASE NUMBER: C13613 ABSTRACTUsing ES-cells, JHU researchers generated a PXE conditional mouse model (floxed Abcc6 allele). When bred to a CMV-cre mouse, this mouse develops robust calcification in the vibrissae (snout of the mouse). They use this mouse model to test...

Published: 3/13/2025 | Inventor(s): Harry Dietz, Shira Ziegler

Keywords(s): Basic Research Biomarker, Cardiovascular Diseases, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Cell Lines, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Cardiovascular