Search Results - roger+johns

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Predicting infection severity and antibody treatment

Unmet NeedThe spectrum of COVID-19 symptomatic infection ranges from mild to critical. Severe illness can occur in healthy individuals of any age, but it predominantly occurs in adults with advanced age or certain underlying medical comorbidities (e.g. cardiovascular disease, diabetes, hypertension, chronic lung disease, obesity). Some prediction tools...

Published: 7/5/2024 | Inventor(s): Roger Johns, Qing Lin, John Skinner

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Antibodies

Prevention of Anesthetic-Induced Neurocognitive Dysfunction

Unmet NeedEvery year in the United States more than one million children under the age of five undergo a surgical procedure that requires anesthesia. Children who have had multiple early exposures to anesthesia are at greater risk of developing learning disabilities and disorders of attention and anxiety. Additionally, animal models that are exposed...

Published: 7/5/2024 | Inventor(s): Roger Johns, Michele Schaefer

Keywords(s): CNS and Neurological Disorders, Cognitive Impairment, Disease Indication, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Psychiatry > Anxiety

A Novel and Unique Set of Human Antibodies to Human Resistin and to Human Resitin-like Molecule Beta (RELMB) that can be used to Target these Proteins in Human Disease

Unmet NeedDiseases resulting from pulmonary remodeling, such as Pulmonary Arterial Hypertension (PAH), Hypertrophic Cardiomyopathy (HCM), Pulmonary Fibrosis (PF) and Chronic Obstructive Pulmonary Disease (COPD) are fatal diseases for which the standards of care are palliative therapies that treat the symptoms of the disease as the patient progresses...

Published: 7/4/2024 | Inventor(s): Roger Johns

Keywords(s): Antibodies, Biologics, Cardiovascular Diseases, Disease Indication, Hypertension, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Hypertension, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities

293 Cell Line for Flag-tagged HIMF (flag-HIMF-293)

C05157: 293 Cell Line for Flag-tagged HIMF (flag-HIMF-293) Technical Details: Hypoxia-induced mitogenic factor (HIMF) is highly up regulated in the lungs as a result of hypoxia-induced pulmonary hypertension, and has proangiogenic and proinflammatory effects in the lung. As a research tool for studying the function and activity of HIMF, JHU researchers...

Published: 7/4/2024 | Inventor(s): Feng Tao, Roger Johns

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

HIMF and related proteins in pulmonary, cardiac and inflammatory disorders

C04858: HIMF and Related Proteins in Pulmonary, Cardiac and Inflammatory Disorders Technical Details: Hypoxia-Induced Mitogenic Factor (HIMF; also known as FIZZ1/RELM) a member of the resistin protein family, is a secreted protein that was found to be highly up regulated in the lungs as a result of hypoxia-induced pulmonary hypertension. HIMF has pro-mitogenic,...

Published: 7/4/2024 | Inventor(s): Hunter Champion, Qingning Su, Roger Johns

Keywords(s): Biomarker, Cardiovascular Diseases, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Inflammatory Disorders, Lung Disorders, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Hypoxia-induced Mitogenic Factor

C04061: Hypoxia-induced Mitogenic FactorValue Proposition: Johns Hopkins University is seeking licensees for Hypoxia-Induced Mitogenic Factor (HIMF/ FIZZ1/RELM), a cell line expressing tagged HIMF, antibodies to HIMF and receptor. HIMF provides a wide array of novel biomarkers and therapeutic targets for lung, vascular, cardiac and inflammatory diseases,...

Published: 7/4/2024 | Inventor(s): Xingwu Teng, Dechun Li, Roger Johns

Keywords(s): Biomarker, Cardiovascular Diseases, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, Hypertension, In Vitro Diagnostics, Inflammatory Disorders, Lung Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Hypertension, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities > Antibodies