Search Results - douglas+robinson

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Protection of lung cells from cigarette smoke, a primary insult causing chronic obstructive pulmonary disease (COPD) and other lung diseases, and ability to increase airway surface hydration and maintain ciliary function.

Unmet NeedChronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death globally by 2030, with cigarette smoke being a major cause. Despite the prevalence of COPD there has been very little progress in developing therapeutic strategy in past 20 years. Thus, mechanistic studies for therapeutic targets for treating...

Published: 6/27/2024 | Inventor(s): Douglas Robinson, Corrine Kliment, Venkataramana Sidhaye, Jennifer Nguyen

Keywords(s): Chronic Obstructive Pulmonary Disorder, Chronic Obstructive Pulmonary Disorder (COPD), Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Lung Disorders

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Respiratory Diseases > Chronic Obstructive Pulmonary Disorder

A versatile method to fabricate giant vesicles that can encapsulate a range of membrane-bound proteins, luminal proteins, and cell lysates under physiologically relevant conditions

Unmet NeedCreating artificial vesicular systems that can mimic natural cells continues to be a challenge in the fields of synthetic biology as well as gene and drug delivery. This class of artificial systems serve as a powerful platform for both studying biology in a minimal, controlled system and moreover can be used as biocompatible vehicles to deliver...

Published: 6/27/2024 | Inventor(s): Shiva Razavi, Takanari Inoue, Tianzhi Luo, Douglas Robinson

Keywords(s): Drug Delivery Vehicle, Therapeutic Matter, Therapeutics, Vesicle

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Activators of Myosin II for Modulating Cell Mechanics

C12770: Novel Panel of Myosin II Activators for Disease Therapy and Tissue EngineeringNovelty:A panel of myosin II activators developed to treat disease and useful for tissue engineering in regenerative medicine.Value Proposition:Changes in cellular mechanics due to impaired activity of myosin II, a motor protein essential for cell division, motility,...

Published: 6/27/2024 | Inventor(s): Douglas Robinson, Alexandra Surcel, Win Pin Ng, Caren Freel Meyers

Keywords(s): Agonists/Promoters, Cancers, Disease Indication, Non-novel, Pancreatic Cancer, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Therapeutic Modalities > Repurposed Drugs