Search Results - takanari+inoue

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Chemically Inducible Hetero-trimerization Tool

Marketing Summary DraftChemically Inducible Hetero-trimerization ToolJHU Ref #: C16287Value Proposition· Chemically Inducible Trimerization (CIT) for introducing a third recruitable component· Addition of rapamycin through rational splitting of FKBP and FRB leads to efficient trimerization· Has robust cellular applications e.g.,...

Published: 6/27/2025 | Inventor(s): Takanari Inoue, Di Wu, Masaki Kikuchi, Onur Dagliyan, Hideki Nakamura, Nikolay Dokholyan, Takashi Umehara

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Intracellular actuator that generates and manipulates physical force in living cells

Marketing Summary DraftIntracellular actuator that generates and manipulates physical force in living cellsJHU Ref #: C14896Value PropositionPhysical force generation inside living cells via light irradiation and chemical treatmentThis research tool can be applied to arbitrary intracellular targets in a specific and spatiotemporal mannerSystem is built...

Published: 6/27/2025 | Inventor(s): Takanari Inoue, Hideki Nakamura, Elmer Rho

Keywords(s): Discovery/Research Tools, Peptides, Recombinant Proteins, Research Reagent, Translational Research Biomarker

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Growth and Site-specific Organization of Micro-scale Bimolecular Devices on Living Mammalian Cells

Unmet Need: One aspect of a cell’s function is its ability to form organized structures both within the cell and with its immediate surrounding environment. On cell surfaces, these nanostructures can serve as scaffolds or operate functionally to aid in cellular fate decisions, signal amplification and cellular cross-talk. There is a need to understand...

Published: 6/27/2025 | Inventor(s): Rebecca Schulman, Sisi Jia, Siew Cheng Phua, Yuta Nihongaki, Yizeng Li, Michael Pacella, Yi Li, Abdul Majeed Mohammed, Sean Sun, Takanari Inoue

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Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

A versatile method to fabricate giant vesicles that can encapsulate a range of membrane-bound proteins, luminal proteins, and cell lysates under physiologically relevant conditions

Unmet NeedCreating artificial vesicular systems that can mimic natural cells continues to be a challenge in the fields of synthetic biology as well as gene and drug delivery. This class of artificial systems serve as a powerful platform for both studying biology in a minimal, controlled system and moreover can be used as biocompatible vehicles to deliver...

Published: 6/27/2025 | Inventor(s): Shiva Razavi, Takanari Inoue, Tianzhi Luo, Douglas Robinson

Keywords(s): Drug Delivery Vehicle, Therapeutic Matter, Therapeutics, Vesicle

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Chemically Inducible Dimerization System Using Gibberellin Analogs and their Binding Proteins

C11777: Chemically Inducible Dimerization System for Studying Signal TransductionNovelty: The technology presents a novel research tool for manipulation of signal transduction using dimerization through modified gibberellins.Value Proposition: The technology is a novel system involving use of gibberellins analogs to manipulate and visualize protein...

Published: 6/26/2025 | Inventor(s): David Meyers, Takafumi Miyamoto, Robert Derose, Takanari Inoue

Keywords(s): Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Molecular Switches/Receptors, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

A Method to Increase Availability of Specific Membrane Lipids (termed "lipid liberation")

C11757: Cell Membrane Lipid “Liberation” for Research UseNovelty: This invention is a method of manipulating the availability of lipids in the plasma membrane on a timescale of seconds.Value Proposition: Currently, there is no technique to effectively change the lipid availability (lipid liberation) in the plasma membrane on a timescale of seconds....

Published: 6/26/2025 | Inventor(s): Tasuku Ueno, Bjorn Falkenburger, Takanari Inoue

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Labels/Markers, Research Instrument, Research Reagent

Category(s): Technology Classifications > Research Tools

Photocleavable Rapamycin Conjugates for Spatiotemporal Control of Small GTPase Activity

C11682: Ultraviolet Light Controlled Activation of Intracellular SignalingNovelty: This invention is an Ultraviolet light controlled method to locally activate GTPases in a specific region of the cell.Value Proposition: Currently, no techniques or tools exist to control the activities of Rho GTPase signaling molecules at precise locations to study cellular...

Published: 6/26/2025 | Inventor(s): Tetsuo Nagano, Tasuku Ueno, Nobuhiro Umeda, Takanari Inoue

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools