Search Results - enzymes

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Diazen-1-ium-1, 2-diolate Derivatives as New Nitroxyl Donors

Unmet NeedHeart failure is a continuously growing health issue in the United States. According to a study by the CDC, approximately 6.2 million Americans had heart failure between the years 2013-2016, and that number is expected to breach 8 million by 2030 (see AHA). Acute decompensated heart failure (ADHF), a potentially fatal cause of respiratory...

Published: 3/13/2025 | Inventor(s): Christopher Pavlos, Preeya Kapur Boppana, John Toscano

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Very Fast and Efficient Light-inducible CRISPR/Cas9 System for Genome Editing

Unmet NeedSince CRISPR has been proposed as a genome editing tool in 2012, it has revolutionized the field and created excitement extending beyond the genome editing scientific community. Due to its simplicity and efficiency, CRISPR-Cas9 systems have already shown promise in multiple fields, e.g., medicine, agriculture and even biofuels (through CRISPR-edited...

Published: 3/14/2025 | Inventor(s): Taekjip Ha, Yang Liu, Roger Zou, Bin Wu

Keywords(s): Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids

A CRISPR-Cas9 Platform with an Intrinsic Off-switch and Enhanced Specificity

Unmet NeedThe CRISPR/Cas9 system is a revolutionary genome editing tool that has opened up new opportunities in biological research and disease treatments. However, prolonged activity of Cas9 endonuclease inside the cell could undermine the efficacy of this system as it increases the risk of deleterious side-effects, such as off-target editing, genotoxicity,...

Published: 3/14/2025 | Inventor(s): Taekjip Ha, Roger Zou, Yang Liu

Keywords(s): Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids

Vibrio Mutants that Convert Chitin Containing Waste Products to N-Acetylglucosamine

Unmet NeedAbout 1011 metric tons of chitin are produced annually in the ocean waters, and chitin is one of the most abundant organic substances in nature. It is a polymer composed of Nacetylglueosamine (GlcNAc) and glucosamine (GIcN) residues. These substances are considered to be valuable as supplements in the treatment of connective tissue diseases...

Published: 3/13/2025 | Inventor(s): Donald Comb, Xibing Li, Saul Roseman

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Expression Plasmid pUC19-PPase for E. coli Pyrophosphatase

Plasmid expression construct for the inorganic pyrophosphatase (PPase) gene of E. coli with its native promoter, Shine-Dalgarno sequence, and terminator. The gene was PCR-amplified from E. coli K12 genomic DNA and cloned into pUC19, and the sequence of the insert was verified by sequencing. The purified PPase is used as a coupling enzyme in a novel...

Published: 3/13/2025 | Inventor(s): James Stivers, Kyle Seamon

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Enzymes, Plasmid, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Photocleavable Rapamycin Conjugates for Spatiotemporal Control of Small GTPase Activity

C11682: Ultraviolet Light Controlled Activation of Intracellular SignalingNovelty: This invention is an Ultraviolet light controlled method to locally activate GTPases in a specific region of the cell.Value Proposition: Currently, no techniques or tools exist to control the activities of Rho GTPase signaling molecules at precise locations to study cellular...

Published: 3/13/2025 | Inventor(s): Tetsuo Nagano, Tasuku Ueno, Nobuhiro Umeda, Takanari Inoue

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Luminescent kinase activity biosensors

C11388: Novel Luminescent Biosensors to Visualize In Vivo Kinase ActivityNovelty: Novel reporters designed to enable sensitive and robust real time visualization of protein kinase activity in vivo in either a population of cells or in a single cell.Value Proposition: Currently available, fluorescence resonance energy transfer (FRET)-based kinase activity...

Published: 3/13/2025 | Inventor(s): Jin Zhang, Michael Allen, Katie Herbst

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Labels/Markers, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Medical Devices > Imaging

Co-translational activation of a transcription factor by proteolytic cleavage

C11384: Novel Method for Real Time Monitoring of Gene ExpressionNovelty: The invention is a novel method which allows the targeted activation and characterization of a protein molecule of interest in a living cell without disrupting its natural state or functionality.Value Proposition: Currently, protein expression can be followed using translation...

Published: 3/13/2025 | Inventor(s): Jie Xiao, Zachary Hensel

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Emission Ratiometric Kinase Activity Reports in High Throughput Drug Screening and Analysis

Unmet Need: Genetically-encoded reporters based on fluorescence resonance energy transfer (FRET) have become powerful tools for monitoring the activities of protein kinases and second messengers in live-cell imaging, but their application in high throughput assays has yet to be realized. Protein phosphorylation is one of the major regulatory mechanisms...

Published: 3/13/2025 | Inventor(s): Qiang Ni, Michael Allen, Jin Zhang

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays

Use of NADPH-dependent alkenal/one oxidoreductase in the Bioactivation of Irofulven and Related Compounds that Preferentially Kill Cancer Cells

C04330: Use of NADPH-dependent alkenal/one oxidoreductase in the Bioactivation of Irofulven and Related Compounds that Preferentially Kill Cancer Cells Technical Details: Irofulven (6-hydroxymethylacylfulvene, HMAF) is a novel anticancer chemotherapeutic that is under extensive clinical evaluation. It is an alkylating agent that is capable of forming...

Published: 3/13/2025 | Inventor(s): Ryan Dick

Keywords(s): Biologics, Cancers, Discovery/Research Tools, Disease Indication, Enzyme, Enzymes, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

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