Search Results - jin+zhang

6 Results

Sort By:

Phosphonetworks.org: A Database for a High Resolution Map of Phosphorylation Networks in Humans

Database for a High Resolution Map of Phosphorylation Networks in HumansJHU REF: [C12682] Invention noveltyA high resolution map of a protein modification, phosphorylation, in humans Value Proposition Protein phosphorylation, mediated by protein kinases, is one of the essential regulatory mechanisms in eukaryotes. Biochemical analysis of kinase-substrate...

Published: 6/27/2024 | Inventor(s): Heng Zhu, Jiang Qian, Jin Zhang

Keywords(s): Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software

Luminescent kinase activity biosensors

C11388: Novel Luminescent Biosensors to Visualize In Vivo Kinase ActivityNovelty: Novel reporters designed to enable sensitive and robust real time visualization of protein kinase activity in vivo in either a population of cells or in a single cell.Value Proposition: Currently available, fluorescence resonance energy transfer (FRET)-based kinase activity...

Published: 6/27/2024 | Inventor(s): Jin Zhang, Michael Allen, Katie Herbst

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Labels/Markers, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Medical Devices > Imaging

New Designs for Emission Ratiometric Reporters of Kinase Activities

C10155: Reporters for Visualizing Signaling Pathways in Living CellsValue Proposition: Protein kinases and phosphatases are crucial components of intracellular signaling pathways which transmit signals by phosphorylation of downstream targets, altering their function. Efficient signal transduction requires precise kinase regulation within specific biological...

Published: 6/27/2024 | Inventor(s): Michael Allen, Xinxin Gao, Robert Newman, Matthew Fosbrink, Jin Zhang

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Labels/Markers, Research Instrument, Research Reagent, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays

Emission Ratiometric Kinase Activity Reports in High Throughput Drug Screening and Analysis

Unmet Need: Genetically-encoded reporters based on fluorescence resonance energy transfer (FRET) have become powerful tools for monitoring the activities of protein kinases and second messengers in live-cell imaging, but their application in high throughput assays has yet to be realized. Protein phosphorylation is one of the major regulatory mechanisms...

Published: 7/4/2024 | Inventor(s): Qiang Ni, Michael Allen, Jin Zhang

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays

Emission Ratiometric Indicators of Phosphoinositides

C04722: Spatiotemporal FRET Reporter for PhosphoinositidesNovelty: This technology is a novel reporter molecule with the capability of revealing very specific spatial and temporal information for production and degradation of phosphatidylinositols (PI) PIP(3,4)2 and PIP3. Phosphatidylinositols are a diverse family of lipid second messengers with important...

Published: 7/4/2024 | Inventor(s): Bharath Ananthanarayanan, Jin Zhang

Keywords(s): Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Molecular Switches/Receptors, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Emission Ratiometric Indicators of Intracellular Cyclic AMP and Epac Activation

Unmet Need: Spatial and temporal control of cAMP signaling is crucial to differential regulation of cellular targets involved in various signaling cascades. Various methods exist for detecting and measuring intracellular cAMP, but none are ideally suited for monitoring spatial and temporal distributions of cAMP in living cells. Here, inventors developed...

Published: 7/4/2024 | Inventor(s): Lisa DiPilato, Jin Zhang

Keywords(s): Assay, Clinical Diagnostics, In Vitro Diagnostics

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools