Search Results - michael+allen

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C11388: Novel Luminescent Biosensors to Visualize In Vivo Kinase ActivityNovelty: Novel reporters designed to enable sensitive and robust real time visualization of protein kinase activity in vivo in either a population of cells or in a single cell.Value Proposition: Currently available, fluorescence resonance energy transfer (FRET)-based kinase activity...

Published: 7/4/2024 | Inventor(s): Jin Zhang, Michael Allen, Katie Herbst

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Labels/Markers, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Medical Devices > Imaging

New Designs for Emission Ratiometric Reporters of Kinase Activities

C10155: Reporters for Visualizing Signaling Pathways in Living CellsValue Proposition: Protein kinases and phosphatases are crucial components of intracellular signaling pathways which transmit signals by phosphorylation of downstream targets, altering their function. Efficient signal transduction requires precise kinase regulation within specific biological...

Published: 7/4/2024 | Inventor(s): Michael Allen, Xinxin Gao, Robert Newman, Matthew Fosbrink, Jin Zhang

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Labels/Markers, Research Instrument, Research Reagent, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays

Emission Ratiometric Kinase Activity Reports in High Throughput Drug Screening and Analysis

Unmet Need: Genetically-encoded reporters based on fluorescence resonance energy transfer (FRET) have become powerful tools for monitoring the activities of protein kinases and second messengers in live-cell imaging, but their application in high throughput assays has yet to be realized. Protein phosphorylation is one of the major regulatory mechanisms...

Published: 7/4/2024 | Inventor(s): Qiang Ni, Michael Allen, Jin Zhang

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays