Search Results - roger+zou

4 Results

Sort By:

Improving the sensitivity of CRISPR off-target detection through modulation of DNA repair

Value Proposition:· Utilizes components of existing workflow to better detect off-target gene editing· Capable for use in in vivo or in vitro settings· Maximizes impact of CRISPR-Cas9 in therapeutic developmentTechnology Description· Researchers at Johns Hopkins have developed a method to detect off-target editing with high...

Published: 10/4/2024 | Inventor(s): Roger Zou, Yang Liu, Taekjip Ha, Oscar Reyes Gaido

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Nucleic Acid Detection Using a CRISPR Nuclease Actuator

Unmet Need / Invention Novelty: Nucleic acid-based diagnostics are useful for detection of infection, disease, and/or genetic variants. There is a need to develop improved detection methods with enhanced speed, specificity, sensitivity, at low cost that can be used for diagnostic applications.Technical Details: Researchers at Johns Hopkins have developed...

Published: 10/4/2024 | Inventor(s): Taekjip Ha, Roger Zou

Keywords(s):

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics

Very Fast and Efficient Light-inducible CRISPR/Cas9 System for Genome Editing

Unmet NeedSince CRISPR has been proposed as a genome editing tool in 2012, it has revolutionized the field and created excitement extending beyond the genome editing scientific community. Due to its simplicity and efficiency, CRISPR-Cas9 systems have already shown promise in multiple fields, e.g., medicine, agriculture and even biofuels (through CRISPR-edited...

Published: 10/4/2024 | Inventor(s): Taekjip Ha, Yang Liu, Roger Zou, Bin Wu

Keywords(s): Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids

A CRISPR-Cas9 Platform with an Intrinsic Off-switch and Enhanced Specificity

Unmet NeedThe CRISPR/Cas9 system is a revolutionary genome editing tool that has opened up new opportunities in biological research and disease treatments. However, prolonged activity of Cas9 endonuclease inside the cell could undermine the efficacy of this system as it increases the risk of deleterious side-effects, such as off-target editing, genotoxicity,...

Published: 10/4/2024 | Inventor(s): Taekjip Ha, Roger Zou, Yang Liu

Keywords(s): Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids