Search Results - yang+liu

6 Results

Sort By:

Improving the sensitivity of CRISPR off-target detection through modulation of DNA repair

Value Proposition:· Utilizes components of existing workflow to better detect off-target gene editing· Capable for use in in vivo or in vitro settings· Maximizes impact of CRISPR-Cas9 in therapeutic developmentTechnology Description· Researchers at Johns Hopkins have developed a method to detect off-target editing with high...

Published: 3/14/2025 | Inventor(s): Roger Zou, Yang Liu, Taekjip Ha, Oscar Reyes Gaido

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Detection of Prostate Cancer Proteins in Serum for Cancer Diagnosis with a Blood Test

There is a crucial need of discovering novel biomarkers in addition to prostate specific antigen (PSA) to improve the specificity of clinical diagnosis for prostate cancer. This invention addresses this problem by discovering proteins from prostate cancer tissues that can be detected in patients’ blood. Hence, a blood test can be developed for detecting...

Published: 3/13/2025 | Inventor(s): Yan Li, Daniel Chan, Zhen Zhang, Lori Sokoll, Hui Zhang

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Prostate Cancer

Computational Head Model with Orbit (CHMO) Simulating Optic Nerve Injury Under Blunt Impact

Computational Head Model with Orbit (CHMO) Simulating Optic Nerve Injury Under Blunt Impact Case ID:C16069Disclosure Date:1/9/2020 Unmet need The Mayo Clinic estimates that over 200,000 traumatic brain injuries (TBIs) occur in the United States every year, usually as consequences of car accidents and contact sports. TBIs are associated with a variety...

Published: 3/14/2025 | Inventor(s): Nitin Daphalapurkar, Eric Singman, Timothy McCulley, Yang Li

Keywords(s):

Category(s): Clinical and Disease Specializations > Traumatic Injury, Clinical and Disease Specializations > Ophthalmology > Optic Neuropathy, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence

Very Fast and Efficient Light-inducible CRISPR/Cas9 System for Genome Editing

Unmet NeedSince CRISPR has been proposed as a genome editing tool in 2012, it has revolutionized the field and created excitement extending beyond the genome editing scientific community. Due to its simplicity and efficiency, CRISPR-Cas9 systems have already shown promise in multiple fields, e.g., medicine, agriculture and even biofuels (through CRISPR-edited...

Published: 3/14/2025 | Inventor(s): Taekjip Ha, Yang Liu, Roger Zou, Bin Wu

Keywords(s): Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids

A CRISPR-Cas9 Platform with an Intrinsic Off-switch and Enhanced Specificity

Unmet NeedThe CRISPR/Cas9 system is a revolutionary genome editing tool that has opened up new opportunities in biological research and disease treatments. However, prolonged activity of Cas9 endonuclease inside the cell could undermine the efficacy of this system as it increases the risk of deleterious side-effects, such as off-target editing, genotoxicity,...

Published: 3/14/2025 | Inventor(s): Taekjip Ha, Roger Zou, Yang Liu

Keywords(s): Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids

Targeting Collagen Strands for Imaging and Therapy

C11749: Novel Collagen Targeting for Imaging and Therapeutic ApplicationsNovelty: This technology employs collagen mimetic peptides to target denatured collagen in vivo for imaging and treatment of cancer and other diseases affecting the collagen matrix.Value Proposition: There are currently no available means of targeting a denatured collagen matrix...

Published: 3/13/2025 | Inventor(s): Yang Li, Catherine Foss, Allen Yi-Lan Wang, Martin Pomper, Daniel Summerfield, Michael Yu

Keywords(s): Biologics, Cancers, Cardiovascular Diseases, Disease Indication, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Peptide, Radioisotope Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities