Search Results - oscar+reyes+gaido

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An ultrasensitive, genetically encoded CaMKII fluorescent biosensor and its uses

Unmet Need According to the CDC, heart disease is the leading cause of death for men and women in the United States. About 6.2 million adults in the United States have heart failure. The Ca2+ and Calmodulin dependent protein kinase II (CaMKII) is a known driver of heart injury, promoting heart failure, arrhythmias and death. There is great interest...

Published: 3/14/2025 | Inventor(s): Oscar Reyes Gaido, Mark Anderson, Elizabeth Luczak

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Category(s): Technology Classifications > Research Tools > Assays

Improving the sensitivity of CRISPR off-target detection through modulation of DNA repair

Value Proposition:· Utilizes components of existing workflow to better detect off-target gene editing· Capable for use in in vivo or in vitro settings· Maximizes impact of CRISPR-Cas9 in therapeutic developmentTechnology Description· Researchers at Johns Hopkins have developed a method to detect off-target editing with high...

Published: 3/14/2025 | Inventor(s): Roger Zou, Yang Liu, Taekjip Ha, Oscar Reyes Gaido

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Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms