Search Results - taekjip+ha

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Value Proposition· Enhanced accuracy: These enzymes may be used to more accurately sequence DNA · Study control: light activated enzymes may be used for precise manipulation of helicases to be used for in-cell studies.Unmet Need· The enzymatic activity for DNA transcription and translation is frequently used in research and commercial...

Published: 6/27/2025 | Inventor(s): Taekjip Ha, Dmitriy Bobrovnikov, Yann Chemla, Monika Makurath

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Bio-engineered enzymes to replace thermal cycler machine in PCR

Unmet NeedThe COVID-19 pandemic underscored the importance of rapid and sensitive testing for infectious material to limit the spread of a virus. The gold standard of testing is detection of viral DNA by polymerase chain reaction (PCR). PCR has long been used in laboratory settings and can reliably detect viral infection at a highly sensitive level...

Published: 6/27/2025 | Inventor(s): Taekjip Ha, Momcilo Gavrilov

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Genome Oligopaint via Local Denaturation Fluorescence in Situ Hybridization (GOLD FISH)

Unmet NeedSince its implementation in the 1960s, DNA fluorescence in situ hybridization (DNA FISH) has grown to be an important, powerful and sensitive technique for the detection of chromosomal abnormalities and changes in gene expression levels in microbes, cells and tissues for research and diagnostic applications. For example, in breast cancer DNA...

Published: 6/27/2025 | Inventor(s): Taekjip Ha, Yanbo Wang, Wayne Cottle

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Improving the sensitivity of CRISPR off-target detection through modulation of DNA repair

Value Proposition:· Utilizes components of existing workflow to better detect off-target gene editing· Capable for use in in vivo or in vitro settings· Maximizes impact of CRISPR-Cas9 in therapeutic developmentTechnology Description· Researchers at Johns Hopkins have developed a method to detect off-target editing with high...

Published: 6/27/2025 | Inventor(s): Roger Zou, Yang Liu, Taekjip Ha, Oscar Reyes Gaido

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Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Nucleic Acid Detection Using a CRISPR Nuclease Actuator

Unmet Need / Invention Novelty: Nucleic acid-based diagnostics are useful for detection of infection, disease, and/or genetic variants. There is a need to develop improved detection methods with enhanced speed, specificity, sensitivity, at low cost that can be used for diagnostic applications.Technical Details: Researchers at Johns Hopkins have developed...

Published: 6/27/2025 | Inventor(s): Taekjip Ha, Roger Zou

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Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics

Platform for Population-Scale Screening of COVID-19 Antibodies

Unmet NeedCOVID-19 is a disease caused by the novel coronavirus SARS-CoV-2. As of September 2020, there are over 33 million cases of COVID-19 globally, resulting in 1 million deaths from the virus. Due to diverse individual responses to the virus and limited testing, it has been particularly hard to identify individuals that present no or mild symptoms...

Published: 6/27/2025 | Inventor(s): Netzahualcoyotl Arroyo, Jamie Spangler, Taekjip Ha, Elissa Leonard, Miguel Aller Pellitero, Soojung Hur, Harrison Khoo

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Category(s): Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics

Very Fast and Efficient Light-inducible CRISPR/Cas9 System for Genome Editing

Unmet NeedSince CRISPR has been proposed as a genome editing tool in 2012, it has revolutionized the field and created excitement extending beyond the genome editing scientific community. Due to its simplicity and efficiency, CRISPR-Cas9 systems have already shown promise in multiple fields, e.g., medicine, agriculture and even biofuels (through CRISPR-edited...

Published: 6/27/2025 | Inventor(s): Taekjip Ha, Yang Liu, Roger Zou, Bin Wu

Keywords(s): Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids

A CRISPR-Cas9 Platform with an Intrinsic Off-switch and Enhanced Specificity

Unmet NeedThe CRISPR/Cas9 system is a revolutionary genome editing tool that has opened up new opportunities in biological research and disease treatments. However, prolonged activity of Cas9 endonuclease inside the cell could undermine the efficacy of this system as it increases the risk of deleterious side-effects, such as off-target editing, genotoxicity,...

Published: 6/27/2025 | Inventor(s): Taekjip Ha, Roger Zou, Yang Liu

Keywords(s): Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids

A New Method to Suppress Background Noise in Stimulated Emission Depletion (STED) Nanoscopy

Unmet NeedDifferentiating small features, such a membrane fibrils in a cell, or small entities, such as viruses, is made possible by high resolution fluorescence imaging. Stimulated Emission Depletion (STED) Nanoscopy has proven to produce images that can overcome the diffraction limit and provide nanometer resolution of fluorescently labeled samples....

Published: 6/27/2025 | Inventor(s): Taekjip Ha, Jong-Chan Lee, Ye Ma

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Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging