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Intranasal Administration of Glutamate Carboxypeptidase (GCP-II) Inhibitors for Enhanced Brain Delivery

Inventors have developed a novel method to enhance the penetrance of multiple GCPII inhibitors which were developed by the inventor and Dr. Pomper at JHU. This method demonstrated improved brain penetrance in rodents. The penetrance of a specific GCPII inhibitor showed significant brain penetrance in non-human primates and inhibited GCPII activity in...

Published: 9/26/2024 | Inventor(s): Rana Rais, Barbara Slusher

Keywords(s): Biologics, CNS and Neurological Disorders, Disease Indication, Drug Delivery Mechanism, Enzyme, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Intranasal Administration, Multiple CNS Indications, Positron Emission Tomography (PET), Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

Mutational analysis of the tyrosine phosphatome in colorectal cancers

Technical Details: JHU researchers have performed a comprehensive mutational analysis of the protein tyrosine phosphatases super gene family in colorectal tumors and other cancers. It was discovered that the mutated tyrosine phosphatases are tumor suppressor genes, regulating pathways that may be amendable to therapeutic intervention Looking...

Published: 9/26/2024 | Inventor(s): Kenneth Kinzler, Bert Vogelstein, Zhenghe Wang, Victor Velculescu

Keywords(s): Biologics, Cancers, Colorectal Cancer, Disease Indication, Enzyme, Gene Therapy, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

pFex: An Adenoviral Fiber Exchange Shuttle System

Technical Details: The value of re-targeted adenoviral vectors is becoming apparent in the current age of gene therapy. However, the large size and complex organization of adenoviral vectors makes construction of re-targeted viral genomes difficult. The described invention, pFex, provides a very flexible system for the insertion of re-targeted genes...

Published: 9/26/2024 | Inventor(s): Shawn Lupold, Wasim Chowdhury, Ronald Rodriguez

Keywords(s): Basic Research Biomarker, Biologics, Cloning Reagents, Discovery/Research Tools, Enzyme, In Vitro Research Tool, Plasmid, Protein, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Vectors & Plasmids

Use of NADPH-dependent alkenal/one oxidoreductase in the Bioactivation of Irofulven and Related Compounds that Preferentially Kill Cancer Cells

C04330: Use of NADPH-dependent alkenal/one oxidoreductase in the Bioactivation of Irofulven and Related Compounds that Preferentially Kill Cancer Cells Technical Details: Irofulven (6-hydroxymethylacylfulvene, HMAF) is a novel anticancer chemotherapeutic that is under extensive clinical evaluation. It is an alkylating agent that is capable of forming...

Published: 9/26/2024 | Inventor(s): Ryan Dick

Keywords(s): Biologics, Cancers, Discovery/Research Tools, Disease Indication, Enzyme, Enzymes, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities