Search Results - ronald+rodriguez

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DPL: Packaging Cell Line For Diphtheria Toxin Expressing Non-replicating Adenovirus

The invention provides a packaging cell line for production of diphtheria toxin (DT) expressing, non-replicating adenovirus for use in suicide gene therapy of cancer cells, as well as production of immunotoxins. Also provided are methods for producing diphtheria toxin (DT) expressing, non-replicating adenovirus, methods for producing immunotoxins, and...

Published: 6/20/2024 | Inventor(s): Wasim Chowdhury, Ronald Rodriguez

Keywords(s): Adeno Virus, Biologics, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Infectious Diseases, Polypeptide, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Viruses, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Peptides

PSMA-retargeted adenovirus

C11155: Method of developing targeted therapeutic agents for cancer using adenovirusValue Proposition: • Addresses a major patient need. • Specific for the target. • Enhances adenoviral gene therapy. • Has therapeutic and diagnostic applications. Technical Details: JHU scientists have developed a successful strategy to optimize targeted...

Published: 6/20/2024 | Inventor(s): Ping Wu, Ronald Rodriguez, Shawn Lupold

Keywords(s): Antigens, Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Plasmid/Vector, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Host Defense Turned Viral Offense; Engineering the Next Generation of Oncolytic Adenoviruses

C10910: Use of RNA Interference and Adenovirus Therapy against Prostate CancerValue Proposition: • Addresses a major patient need • Enhances the therapeutic efficacy of CRAd strategy • Creates the bases to develop enhanced oncolytic viral gene therapies with shRNA Technical Details: Prostate cancer is one of the most aggressive cancers...

Published: 6/20/2024 | Inventor(s): Naser Hoti, Ronald Rodriguez

Keywords(s): Biologics, Cancers, Cell Therapy/Immunotherapy, Combination, Disease Indication, Drug Delivery Vehicle, Nucleic Acid, Plasmid/Vector, Prostate Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber

C10152: A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber Technical Details: Capsid-displayed adenoviral peptide libraries have been a significant yet unfeasible goal in biotechnology. Three barriers have made this difficult: the large size of the viral genome, the low efficiency of converting plasmid-based...

Published: 6/20/2024 | Inventor(s): Ronald Rodriguez, Wasim Chowdhury, Tarana Kudrolli, Shawn Lupold

Keywords(s): Adeno Virus, Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent, Viruses

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Viruses

pFex: An Adenoviral Fiber Exchange Shuttle System

Technical Details: The value of re-targeted adenoviral vectors is becoming apparent in the current age of gene therapy. However, the large size and complex organization of adenoviral vectors makes construction of re-targeted viral genomes difficult. The described invention, pFex, provides a very flexible system for the insertion of re-targeted genes...

Published: 6/20/2024 | Inventor(s): Shawn Lupold, Wasim Chowdhury, Ronald Rodriguez

Keywords(s): Basic Research Biomarker, Biologics, Cloning Reagents, Discovery/Research Tools, Enzyme, In Vitro Research Tool, Plasmid, Protein, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Vectors & Plasmids

Enhancement of Adenoviral Oncolytic Activity by Modification of the E1A Gene Product

Unmet Need: Prostate cancer is a multi-focal disease with clones of androgen-sensitive and androgen-refractory cells, yet, the specific role androgen receptors (ARs) may play in prostate cancer in not clear. There remains an unmet need for new specific treatment modalities that selectively target diseased tissue and are capable of effectively killing...

Published: 6/20/2024 | Inventor(s): Ying Li, Ronald Rodriguez

Keywords(s): Cancers, Disease Indication, Prostate Cancer, Therapeutic Matter, Therapeutics