Search Results - shawn+lupold

6 Results

Sort By:

Radiation Sensitization Agents for Prostate Cancer

Radiation Sensitization Agents for Prostate CancerJHU REF: [C11146] Invention novelty: A new mechanism to selectively sensitize the prostate to radiation therapy by knocking down DNA repair gene transcripts. Value Proposition: Current dose-escalated radiation therapy for localized prostate cancer treatment has increased the risk of injury of surrounding...

Published: 6/20/2024 | Inventor(s): Xiaohua Ni, Yonggang Zhang, Theodore DeWeese, Shawn Lupold

Keywords(s): Biologics, Cancers, Disease Indication, Nucleic Acid, Prostate Cancer, Radiotherapy, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

PSMA-based Molecular-genetic Reporter System

PSMA-based Molecular-genetic Reporter SystemJHU REF: C12881Invention Novelty: A method of using the prostate-specific membrane antigen (PSMA) in combination with molecular reporting systems as an expression system to deliver the PSMA gene for diagnosis and imaging of prostate cancer.Value Proposition:PSMA is ideally suited to becoming a reporter because...

Published: 6/20/2024 | Inventor(s): Martin Pomper, Shawn Lupold, Mark Castanares, Il Minn

Keywords(s): Antigens, Basic Research Biomarker, Cancers, Cell Signaling, Discovery/Research Tools, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Positron Emission Tomography (PET), Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Medical Devices, Technology Classifications > Research Tools

PSMA-retargeted adenovirus

C11155: Method of developing targeted therapeutic agents for cancer using adenovirusValue Proposition: • Addresses a major patient need. • Specific for the target. • Enhances adenoviral gene therapy. • Has therapeutic and diagnostic applications. Technical Details: JHU scientists have developed a successful strategy to optimize targeted...

Published: 6/20/2024 | Inventor(s): Ping Wu, Ronald Rodriguez, Shawn Lupold

Keywords(s): Antigens, Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Plasmid/Vector, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber

C10152: A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber Technical Details: Capsid-displayed adenoviral peptide libraries have been a significant yet unfeasible goal in biotechnology. Three barriers have made this difficult: the large size of the viral genome, the low efficiency of converting plasmid-based...

Published: 6/20/2024 | Inventor(s): Ronald Rodriguez, Wasim Chowdhury, Tarana Kudrolli, Shawn Lupold

Keywords(s): Adeno Virus, Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent, Viruses

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Viruses

pFex: An Adenoviral Fiber Exchange Shuttle System

Technical Details: The value of re-targeted adenoviral vectors is becoming apparent in the current age of gene therapy. However, the large size and complex organization of adenoviral vectors makes construction of re-targeted viral genomes difficult. The described invention, pFex, provides a very flexible system for the insertion of re-targeted genes...

Published: 6/20/2024 | Inventor(s): Shawn Lupold, Wasim Chowdhury, Ronald Rodriguez

Keywords(s): Basic Research Biomarker, Biologics, Cloning Reagents, Discovery/Research Tools, Enzyme, In Vitro Research Tool, Plasmid, Protein, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Vectors & Plasmids

Extracellular PSMA Fusion Protein, Recombinant Baculovirus, and Plasmid Vectors

C04232: Extracellular PSMA Fusion Protein, Recombinant Baculovirus, and Plasmid VectorsTechnical Details: The invention provides the means to purify large quantities of a fusion protein containing the entire extracellular segment of the human Prostate Specific Membrane Antigen (also known as PSMA, glutamate carboxypeptidase II, folate hydrolase, and...

Published: 6/20/2024 | Inventor(s): Donald Coffey, Brian Hicke, Shawn Lupold

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools