Search Results - polypeptide

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HIF-1

The purified and characterization of hypoxia-inducible factor 1 (HIF-1) is described. HIF-1 is composed of subunits HIF-1 and HIF-1 . Purified HIF-1 polypeptide, its amino acid sequence and polynucleotide sequence are provided. A HIF-1 variant that dimerizes to HIF-1 producing a nonfunctional HIF-1 complex is described. Methods for the prevention and...

Published: 9/26/2024 | Inventor(s): Gregg Semenza

Keywords(s): Biologics, Cardiovascular Diseases, Disease Indication, Polypeptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides

DPL: Packaging Cell Line For Diphtheria Toxin Expressing Non-replicating Adenovirus

The invention provides a packaging cell line for production of diphtheria toxin (DT) expressing, non-replicating adenovirus for use in suicide gene therapy of cancer cells, as well as production of immunotoxins. Also provided are methods for producing diphtheria toxin (DT) expressing, non-replicating adenovirus, methods for producing immunotoxins, and...

Published: 9/26/2024 | Inventor(s): Wasim Chowdhury, Ronald Rodriguez

Keywords(s): Adeno Virus, Biologics, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Infectious Diseases, Polypeptide, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Viruses, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Peptides

Multiple Roles of Cholesterol in Hedgehog Protein Biogenesis and Signaling

The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport...

Published: 9/26/2024 | Inventor(s): Michael Cooper, Jeffrey Porter, Philip Beachy

Keywords(s): Biologics, Biomarker, Cardiovascular Diseases, Disease Indication, Mechanism-of-action Biomarker, Polypeptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Cardiovascular

Selective Prodrug Activation in Cancer Cells Using Protein Switches

Unmet Need: Gene-directed enzyme prodrug therapy (GDEPT; also known as “suicide gene therapy”) is an emerging gene therapy strategy against cancer. A prodrug is systemically administered but only activated in cancer cells that have previously been modified to express an enzyme capable of activating the drug. Yet, the clinical utility of GDEPT to date...

Published: 9/26/2024 | Inventor(s): Chapman Wright, Marc Ostermeier

Keywords(s): Biologics, Biomarker, Cancers, Disease Indication, Gene Therapy, Mechanism-of-action Biomarker, Polypeptide, Protein, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type