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Multiple Roles of Cholesterol in Hedgehog Protein Biogenesis and Signaling

The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport...

Published: 9/26/2024 | Inventor(s): Michael Cooper, Jeffrey Porter, Philip Beachy

Keywords(s): Biologics, Biomarker, Cardiovascular Diseases, Disease Indication, Mechanism-of-action Biomarker, Polypeptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Cardiovascular