Search Results - philip+beachy

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C04341 & C04342 - Small molecule modulators of Wnt and Hedgehog pathways

Unmet Need:Wnt and Hedgehog are important signaling pathways involved in cellular proliferation and differentiation. Both pathways have been shown to play roles in the development, growth and migration of different types of cancer, including colorectal, prostate, lung, breast, and brain cancer. Therefore, cancer researchers hope that modulators /inhibitors...

Published: 10/3/2024 | Inventor(s): Anssi Jussi Taipale, James Chen, Philip Beachy

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Novel, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities

Multiple Roles of Cholesterol in Hedgehog Protein Biogenesis and Signaling

The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport...

Published: 10/3/2024 | Inventor(s): Michael Cooper, Jeffrey Porter, Philip Beachy

Keywords(s): Biologics, Biomarker, Cardiovascular Diseases, Disease Indication, Mechanism-of-action Biomarker, Polypeptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Cardiovascular

Arsenic compounds for Hedgehog pathway blockade in proliferative disorders, including hematopoietic malignancies

INVENTION NOVELTYJohns Hopkins researchers have developed a novel Hedgehog signaling pathway inhibitor that can be used in the treatment of various types of leukemia.VALUE PROPOSITIONThe Hedgehog (Hh) pathway has been found to be important in a number of cancers. Various Hh inhibitors, specifically Smo antagonists, are in development or have been launched...

Published: 10/3/2024 | Inventor(s): Jynho Kim, Philip Beachy

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Non-novel, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

293 ShhN

C12239: Novel Cell Line Used in Hh ligand ProductionNovelty: This tangible material is a 293 ShhN cell line for production of soluble, active Sonic Hh (Shh) ligand.Value Proposition: The most well-known Hh pathway ligand, Sonic Hh (Shh), has been shown to participate in development of the central nervous system. This technology, by enabling production...

Published: 10/3/2024 | Inventor(s): Philip Beachy

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Signaling, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Molecular Switches/Receptors, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

Smo Deficient Embryonic Fibroblast Cell Line_Smo4-/-

C11093: Sonic hedgehog-responsive cell line that lacks functional Smoothened protein Technical Details: The material is a Sonic hedgehog-responsive cell line that lacks functional Smoothened protein. Smoothened is a major target of antineoplastic agents, which gives the cell line the commercial utility. Looking for Partners: The cell line can...

Published: 10/3/2024 | Inventor(s): Anssi Jussi Taipale, Philip Beachy

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

PXA1, PXA2, PXA3, PXA4, PXA5, PXA6

C04411: PXA1, PXA2, PXA3, PXA4, PXA5, PXA6 Technical Details: The invention consists of low-passage cell lines generated from primary pancreatic cancers established as nude-mice xenografts, and subsequently passaged in vitro.Looking for Partners: Due to their low-passage, these cell lines are more representative of the alterations in the pancreatic...

Published: 10/3/2024 | Inventor(s): Sunil Karhadkar, David Berman, Anirban Maitra, Philip Beachy

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model, Mouse Model Xenograft, Pancreatic Cancer, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology > Pancreatic Cancer

Shh Light2 Cells

C04409: Shh Light2 Cells Technical Details: Cell line derived from the NIH/3T3 cell line transfected with GLI-responsive Firefly luciferase reporter from H. Sasaki and a constituitive Renilla-luciferase expression vector. Looking for Partners: Useful as a cell-based research tool for the quantitative assay of biologically active hedgehog proteins....

Published: 10/3/2024 | Inventor(s): Anssi Jussi Taipale, Philip Beachy

Keywords(s): Assay, Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools

293 EcR Shh

C04408: 293 EcR Shh Technical Details: Cell line for ecdysone-inducible expression of Shh. Looking for Partners: This cell line can be used to discover compounds that block activation of the Hh response pathway and abnormal cell growth associated with both types of oncogenic mutation. Publications/Associated Cases: Taipale et al. 2000 “Effects...

Published: 10/3/2024 | Inventor(s): Jeffrey Porter, Philip Beachy

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools