Search Results - anssi+jussi+taipale

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C04341 & C04342 - Small molecule modulators of Wnt and Hedgehog pathways

Unmet Need:Wnt and Hedgehog are important signaling pathways involved in cellular proliferation and differentiation. Both pathways have been shown to play roles in the development, growth and migration of different types of cancer, including colorectal, prostate, lung, breast, and brain cancer. Therefore, cancer researchers hope that modulators /inhibitors...

Published: 6/12/2026 | Inventor(s): Anssi Jussi Taipale, James Chen, Philip Beachy

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Novel, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities

Smo Deficient Embryonic Fibroblast Cell Line_Smo4-/-

Technical Details:The material is a Sonic hedgehog-responsive cell line that lacks functional Smoothened protein. Smoothened is a major target of antineoplastic agents, which gives the cell line the commercial utility.Looking for Partners:The cell line can be used to test Smoothened function or to generate a mouse cell line that expresses only the human...

Published: 6/12/2026 | Inventor(s): Anssi Jussi Taipale, Philip Beachy

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools