Search Results - anssi+jussi+taipale

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C04341 & C04342 - Small molecule modulators of Wnt and Hedgehog pathways

Unmet Need:Wnt and Hedgehog are important signaling pathways involved in cellular proliferation and differentiation. Both pathways have been shown to play roles in the development, growth and migration of different types of cancer, including colorectal, prostate, lung, breast, and brain cancer. Therefore, cancer researchers hope that modulators /inhibitors...

Published: 3/13/2025 | Inventor(s): Anssi Jussi Taipale, James Chen, Philip Beachy

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Novel, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities

Smo Deficient Embryonic Fibroblast Cell Line_Smo4-/-

C11093: Sonic hedgehog-responsive cell line that lacks functional Smoothened protein Technical Details: The material is a Sonic hedgehog-responsive cell line that lacks functional Smoothened protein. Smoothened is a major target of antineoplastic agents, which gives the cell line the commercial utility. Looking for Partners: The cell line can...

Published: 3/13/2025 | Inventor(s): Anssi Jussi Taipale, Philip Beachy

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Shh Light2 Cells

C04409: Shh Light2 Cells Technical Details: Cell line derived from the NIH/3T3 cell line transfected with GLI-responsive Firefly luciferase reporter from H. Sasaki and a constituitive Renilla-luciferase expression vector. Looking for Partners: Useful as a cell-based research tool for the quantitative assay of biologically active hedgehog proteins....

Published: 3/13/2025 | Inventor(s): Anssi Jussi Taipale, Philip Beachy

Keywords(s): Assay, Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools