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Multiple Roles of Cholesterol in Hedgehog Protein Biogenesis and Signaling

The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport...

Published: 9/26/2024 | Inventor(s): Michael Cooper, Jeffrey Porter, Philip Beachy

Keywords(s): Biologics, Biomarker, Cardiovascular Diseases, Disease Indication, Mechanism-of-action Biomarker, Polypeptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Cardiovascular

293 EcR Shh

C04408: 293 EcR Shh Technical Details: Cell line for ecdysone-inducible expression of Shh. Looking for Partners: This cell line can be used to discover compounds that block activation of the Hh response pathway and abnormal cell growth associated with both types of oncogenic mutation. Publications/Associated Cases: Taipale et al. 2000 “Effects...

Published: 9/26/2024 | Inventor(s): Jeffrey Porter, Philip Beachy

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools