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Selective Prodrug Activation in Cancer Cells Using Protein Switches

Unmet Need: Gene-directed enzyme prodrug therapy (GDEPT; also known as “suicide gene therapy”) is an emerging gene therapy strategy against cancer. A prodrug is systemically administered but only activated in cancer cells that have previously been modified to express an enzyme capable of activating the drug. Yet, the clinical utility of GDEPT to date...

Published: 9/26/2024 | Inventor(s): Chapman Wright, Marc Ostermeier

Keywords(s): Biologics, Biomarker, Cancers, Disease Indication, Gene Therapy, Mechanism-of-action Biomarker, Polypeptide, Protein, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type