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HIF-1

The purified and characterization of hypoxia-inducible factor 1 (HIF-1) is described. HIF-1 is composed of subunits HIF-1 and HIF-1 . Purified HIF-1 polypeptide, its amino acid sequence and polynucleotide sequence are provided. A HIF-1 variant that dimerizes to HIF-1 producing a nonfunctional HIF-1 complex is described. Methods for the prevention and...

Published: 6/27/2024 | Inventor(s): Gregg Semenza

Keywords(s): Biologics, Cardiovascular Diseases, Disease Indication, Polypeptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides

HIF-1(alpha)CA5: A Stable and Constitutively-Active Form of HIF-1(alpha)

Technical Overview: Animals and people are dependent on a continuous supply of O(2) for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease. Vascularization and vascular remodeling represent critical adaptive responses to tissue hypoxia...

Published: 6/27/2024 | Inventor(s): Gregg Semenza

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Nucleotide, Research Reagent

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Nucleic Acids

Shape Memory Particles for Biomedical Uses

UNMET NEED Many diseases in the human body are best treated using drug delivery in which a triggered release of extracellular therapeutics or a triggered shape change of intracellular therapeutics mediates the delivery of drugs. However, these therapeutics should only be released under specific circumstances and locations to have the maximum impact...

Published: 6/27/2024 | Inventor(s): Jordan Green, Qiongyu Guo, Randall Meyer, Corey Bishop, Gregg Semenza, Anand Kumar

Keywords(s): Drug Delivery Vehicle, Polymers, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

C03416: HIF-1aDP, A Constitutively-Expressed form of Hypoxia-Inducible Factor 1a

C03416: HIF-1aDP, A Constitutively-Expressed form of Hypoxia-Inducible Factor 1a Technical Details: It has previously been demonstrated that a truncation of HIF-1alpha after amino acid residue 390 results in a constitutively expressed form of the protein. The purpose of this work was to identify mechanisms by which the half-life of the HIF1alpha...

Published: 6/27/2024 | Inventor(s): Gregg Semenza

Keywords(s): Biologics, Cardiovascular Diseases, Disease Indication, Gene Therapy, Natural compounds, Non-novel, Predicted Novelty, Protein, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities

Anti-HIF-1B Antibodies

C03592: Anti-HIF-1B Antibodies Technical Details: Polyclonal antibodies were raised in rabbits and monoclonal antibodies were raised in mice that recognize hypoxia-inducible factor-1? Looking for Partners: These antibodies can be used for biomedical research to detect expression of HIF-1ß in immunoblot, immunoprecipitation, and immunohistochemical...

Published: 6/27/2024 | Inventor(s): Gregg Semenza

Keywords(s): Antibodies, Basic Research Biomarker, Brain Cancer, Cancers, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Monoclonal Antibodies, Mouse Model, Polyclonal Antibodies, Rabbit Model, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Brain Cancer, Technology Classifications > Diagnostics > In Vitro Diagnostics