Search Results - gregg+semenza

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Gene Therapy for Hypoxia Related Conditions and HIF1a mouse monoclonal antibody

The purified and characterization of hypoxia-inducible factor 1 (HIF-1) is described. HIF-1 is composed of subunits HIF-1 and HIF-1 . Purified HIF-1 polypeptide, its amino acid sequence and polynucleotide sequence are provided. A HIF-1 variant that dimerizes to HIF-1 producing a nonfunctional HIF-1 complex is described. Methods for the prevention and...

Published: 5/22/2026 | Inventor(s): Gregg Semenza

Keywords(s): Biologics, Cardiovascular Diseases, Disease Indication, Polypeptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides

HIF-1(alpha)CA5: A Stable and Constitutively-Active Form of HIF-1(alpha)

Technical Overview: Animals and people are dependent on a continuous supply of O(2) for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease. Vascularization and vascular remodeling represent critical adaptive responses to tissue hypoxia...

Published: 5/22/2026 | Inventor(s): Gregg Semenza

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Nucleotide, Research Reagent

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Nucleic Acids

Shape Memory Particles for Biomedical Uses

UNMET NEED Many diseases in the human body are best treated using drug delivery in which a triggered release of extracellular therapeutics or a triggered shape change of intracellular therapeutics mediates the delivery of drugs. However, these therapeutics should only be released under specific circumstances and locations to have the maximum impact...

Published: 5/22/2026 | Inventor(s): Jordan Green, Qiongyu Guo, Randall Meyer, Corey Bishop, Gregg Semenza, Anand Kumar

Keywords(s): Drug Delivery Vehicle, Polymers, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities