Search Results - zhenghe+wang

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Assays to Detect Small Molecules that Suppress Expression of the Mutant Huntington Disease Gene

ABSTRACTHuntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin gene (HTT). JHU researchers approach to finding a treatment for HD is two-fold: 1) to find small molecules (that could be developed into clinically useful drugs) that can directly suppress expression of HTT by blocking activity...

Published: 9/26/2024 | Inventor(s): Russell Margolis, Dobrila Rudnicki, Wang Zheng, Pan Li, Xin Sun

Keywords(s): Assay, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Huntington's Disease, In Vitro Diagnostics, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Mutational analysis of the tyrosine phosphatome in colorectal cancers

Technical Details: JHU researchers have performed a comprehensive mutational analysis of the protein tyrosine phosphatases super gene family in colorectal tumors and other cancers. It was discovered that the mutated tyrosine phosphatases are tumor suppressor genes, regulating pathways that may be amendable to therapeutic intervention Looking...

Published: 9/26/2024 | Inventor(s): Kenneth Kinzler, Bert Vogelstein, Zhenghe Wang, Victor Velculescu

Keywords(s): Biologics, Cancers, Colorectal Cancer, Disease Indication, Enzyme, Gene Therapy, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities