Search Results - intranasal+administration

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Leptin Prevents Opiate-induced Respiratory Depression

Description:Unmet Need The opioid epidemic continues to be a public health crisis, with about 130 Americans dying every day from an opioid overdose. Opiate-mediated respiratory suppression (ORS) is the primary cause of opiate-associated deaths, and obesity greatly increases opiate-related mortality. Obesity also contributes to obstructive sleep apnea...

Published: 3/14/2025 | Inventor(s): Vsevolod Polotsky, David Mendelowitz, Carla Freire

Keywords(s): Biologics, Combination, Drug Delivery Mechanism, Intranasal Administration, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Respiratory Diseases

Intranasal Administration of Glutamate Carboxypeptidase (GCP-II) Inhibitors for Enhanced Brain Delivery

Inventors have developed a novel method to enhance the penetrance of multiple GCPII inhibitors which were developed by the inventor and Dr. Pomper at JHU. This method demonstrated improved brain penetrance in rodents. The penetrance of a specific GCPII inhibitor showed significant brain penetrance in non-human primates and inhibited GCPII activity in...

Published: 3/13/2025 | Inventor(s): Rana Rais, Barbara Slusher

Keywords(s): Biologics, CNS and Neurological Disorders, Disease Indication, Drug Delivery Mechanism, Enzyme, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Intranasal Administration, Multiple CNS Indications, Positron Emission Tomography (PET), Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities