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Improved Obligate Heterodimer FokI Cleavage Domain Variants for Creating Designed Zinc Finger Nucleases with Minimal Cytotoxicity

C11129: Site-specific and Permanent Modification of Genomes with Reduced CytotoxicityNovelty: This technology comprises the generation of re-engineered obligate heterodimer FokI nuclease domain variants to create ZFNs with minimal cell toxicity for targeted modifications in plant, mammalian and even human genomes.Value Proposition: Zinc finger nucleases...

Published: 3/13/2025 | Inventor(s): Sivaprakash Ramalingam, Karthikeyan Kandavelou, Srinivasan Chandrasegaran

Keywords(s): Drug Delivery Vehicle Synthesis Method, Gene Therapy, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities