Search Results - zhiyu+he

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Compositions and Method for Production of Size-Controlled Ternary Nanoparticles for Sustained Release of Peptide Therapeutics

Unmet NeedType 2 diabetes (T2D) contributes to 90% of all cases of diabetes and represents a critical global public health problem. T2D specifically affects glucose metabolism and those with the disease either do not produce enough insulin or do not respond properly to insulin signaling to maintain normal levels of glucose in the blood. Several serious...

Published: 6/28/2024 | Inventor(s): Hai-Quan Mao, Zhiyu He, Yizong Hu, Yongming Chen, Lixin Liu

Keywords(s): Biologics, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

An Insulin-loaded Nanoparticle and the Method for Preparing Thereof

Unmet Need:Repeated injections of insulin is the standard of care for treating Type 1 diabetes, and essential for control and management of Type 2 diabetes. Drawbacks of this treatment include poor patient compliance, discomfort, and an impaired lifestyle, and hypoglycemia. Oral administration of insulin, if successful, could deliver insulin such that...

Published: 6/27/2024 | Inventor(s): Hai-Quan Mao, Jose Santos, Zhiyu He, Huahua Huang, Lixin Liu, Kam Leong, Yongming Chen

Keywords(s): Diabetes, Disease Indication, Drug Delivery Vehicle, Metabolic Disorders, Nanoparticles, Therapeutic Matter, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Real-time dose and risk prediction during target and critical structure delineation for radiotherapy

Unmet NeedCurrent radiotherapy treatment planning is done with the assistance of novel software and technology, based on each patient's specific disease and its unique characteristics. There are no current systems available to provide the clinician with information about prior patients' similar disease characteristics that may help inform a...

Published: 6/27/2024 | Inventor(s): Todd Mcnutt, Harry Quon, Scott Robertson, Joseph Moore, Zhi Cheng

Keywords(s): Cancers, Disease Indication, Image Processing Software, Interventional and Surgical Systems, Surgical Navigation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

A Microfabricated Multiple Actuation Device for Mechanical Conditioning of 3D Microtissues

We have recently demonstrated an approach that enables mechanical stimulation of microtissues via magnetic actuation of magnetic microspheres bonded to one of the cantilevers in each device (ALL THREE ZHAO REFS). This has notably allowed measurement of the mechanical stiffness of such constructs, and hence analysis of the relative contribution of cells...

Published: 6/27/2024 | Inventor(s): Fan Xu, Ruogang Zhao, Tristin Metz, Alan Liu, Yu Shi, Daniel Reich

Keywords(s): Implanted Device, Implants, Therapeutic Devices, Therapeutic Method, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices