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Methods for Continuous Production of Uniform Polyelectrolyte Nanoparticles

Unmet NeedPolyelectrolyte nanoparticles have been widely used for various therapeutic delivery applications, from low molecular weight drugs to peptides and proteins. They are prepared by mixing oppositely charged polymers in aqueous media and are heterogeneous in terms of size and surface charge. However, current production methods rely on bulk mixing...

Published: 6/27/2024 | Inventor(s): Hai-Quan Mao, Jose Santos, Yong Ren, John-Michael Williford

Keywords(s): Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutic Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Compositions of nucleic acid-containing nanoparticles for in vivo delivery

Unmet NeedGene therapy has the potential to offer a one-time cure for severe, debilitating diseases that were previously untreatable or required chronic therapy. While a few viral-based gene therapies have recently received FDA approval, safety concerns around viral-based gene therapies continue to limit their clinical development. Non-viral strategies...

Published: 6/27/2024 | Inventor(s): Hai-Quan Mao, Il Minn, Yong Ren, Jose Santos, John-Michael Williford, Maani Archang, Martin Pomper

Keywords(s): Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

An Insulin-loaded Nanoparticle and the Method for Preparing Thereof

Unmet Need:Repeated injections of insulin is the standard of care for treating Type 1 diabetes, and essential for control and management of Type 2 diabetes. Drawbacks of this treatment include poor patient compliance, discomfort, and an impaired lifestyle, and hypoglycemia. Oral administration of insulin, if successful, could deliver insulin such that...

Published: 6/27/2024 | Inventor(s): Hai-Quan Mao, Jose Santos, Zhiyu He, Huahua Huang, Lixin Liu, Kam Leong, Yongming Chen

Keywords(s): Diabetes, Disease Indication, Drug Delivery Vehicle, Metabolic Disorders, Nanoparticles, Therapeutic Matter, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms