Search Results - stavroula+sofou

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Non-intuitive combination of drug delivery carriers of the same drug for synergistic growth delay of solid tumors

Non-intuitive combination of drug delivery carriers of the same drug for synergistic growth delay of solid tumorsJHU Ref #: C15411 Unmet NeedCancer is the second leading cause of death in the United States, with an estimated 1.8 million cases having been diagnosed and 606,520 people having succumbed to the disease in 2020. The most common cancer diagnosis...

Published: 3/13/2026 | Inventor(s): Stavroula Sofou, Alaina Howe

Keywords(s): Breast Cancer, Cancers, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology

Dendrimer-delivered alpha-particle radiotherapy for treatment of glioblastoma and possibly of other cancers in the brain

#C17436Inventor(s): Stavroula Sofou (primary), Kannan Rangaramanujam, Rajiv NairUnmet NeedGlioblastoma accounts for 49.1 percent of all primary malignant brain tumors. Although current standard of care, which includes surgery, followed by radiotherapy, and chemotherapy, may prolong survival, the five-year survival rate for glioblastoma patients is only...

Published: 3/13/2026 | Inventor(s): Stavroula Sofou, Kannan Rangaramanujam, Rajiv Nair

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Glioblastoma, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Adhesive/adsorption switch on nanoparticles to increase tumor uptake and delay tumor clearance

Unmet NeedEffective drug delivery to solid tumors remains challenging. Outcome failure rates can reach 90% for current therapeutic approaches for solid tumors. The use of nanoparticles for the delivery of therapeutic agents can enhance the safety, pharmacokinetic profile, and bioavailability of administered drugs, leading to improved therapeutic tolerance...

Published: 3/13/2026 | Inventor(s): Stavroula Sofou, Sarah Stras, Alaina Howe, Aprameya Ganesh Prasad, Dominick Salerno

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms