Search Results - scott+kern

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PALB2 Gene Mutations Identify Susceptibility to DNA Damaging Agents

PALB2 Gene Mutations Identify Susceptibility to DNA Damaging AgentsJHU Ref #: C10869Unmet NeedPancreatic cancer is predicted to be the second leading cause of cancer-related death by 2030 (Siegel et al., 2020). However, many patients present with advanced disease, and typical broad-spectrum chemotherapeutic treatments are often insufficient. Precision...

Published: 9/26/2024 | Inventor(s): Ralph Hruban, Bert Vogelstein, Kenneth Kinzler, Victor Velculescu, Scott Kern, Sian Jones, Michael Goggins, Manuel Hidalgo, Alison Klein, James Eshleman, Donald Parsons

Keywords(s): Biomarker, Clinical Diagnostics, In Vitro Diagnostics, Risk Stratification

Category(s): Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Precision Medicine Tools

An Adduct-specific Anti-thymidylate Synthase Antibody for Monitoring Fluorouracil Anticancer Therapy

TITLEAn Adduct-specific Anti-thymidylate Synthase Antibody for Monitoring Fluorouracil Anticancer TherapyCASE NUMBERC11954ABSTRACTWe developed a functional assay for a class of widely used anti-cancer drugs, 5-fluorouracil and related compounds (SFU). It is well established that SFU works largely by inhibiting the enzyme thymidylate synthase (TS) in...

Published: 9/26/2024 | Inventor(s): Kalpeshkumar Patel, Scott Kern

Keywords(s): Antibodies, Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, Monoclonal Antibodies, Pharmakodynamic Biomarker, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

M3 Instructional Guide – Fostering Longterm Charitable Donations by Distributed Publication(s)

TITLE M3 Instructional Guide – Fostering Longterm Charitable Donations by Distributed Publication(s)JHU Ref. #C13885ABSTRACTA promotional message for charitable donations is integrated into an instructional guide for a unique style of guitar playing using major thirds (M3). M3 tuning facilitates...

Published: 9/27/2024 | Inventor(s): Scott Kern

Keywords(s): Copyright

Category(s): Copyright

PALB2 KO Cells: 130-2 and 10-7 (and PALB2 Heterozygotes: 55-7)

C11832: PALB2 Knockout Cell Line for Anti-cancer Drug ScreeningNovelty: Genetically modified human colon cancer cell lines in which either one or both copies of the PALB2 (Partner and Localizer of BRCA2) gene is deleted. These cell lines serve as great cancer drug screening tool.Value Proposition: PALB2 is essential for repairing damaged DNA and is...

Published: 9/26/2024 | Inventor(s): Soma Ghosh, Scott Kern

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

MKK4/MAP2K4 KO Lines for Drug Discovery

C10131: MKK4/MAP2K4 KO Lines for Drug DiscoveryValue Proposition: MKK4 (JNKK1, MAP2K4, and SEK1), a dual-specificity kinase gene on chromosome 17p11, is a tumor suppressor gene that is mutated in a subset of most tumor types. MKK4 protein is activated by several kinases, and active MKK4 cooperates with MKK7 to phosphorylate and thereby activate Jun...

Published: 9/26/2024 | Inventor(s): Steven Cunningham, Eike Gallmeier, Scott Kern

Keywords(s): Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

BRCA2 KO Lines for Drug Discovery

C05188: BRCA2 KO Lines for Drug Discovery Technical Details: BRACA2 is a DNA repair gene. Mutations in BRACA2 cause an inherited risk of breast, ovarian and pancreatic cancers. The cancer cell lines are engineered to lack BRACA2 and are useful screening tools for chemotherapeutic or chemopreventative agentsLooking for Partners: The BRACA2 KO cell...

Published: 9/26/2024 | Inventor(s): Thomas Hucl, Scott Kern

Keywords(s): Breast Cancer, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Ovarian Cancer, Pancreatic Cancer, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Ovarian Cancer, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines

A Functional Assay Distinguishing Pathogenic and Nonpathogenic Variant Alleles of the BRCA2 Gene

C05150: Identification of Pathological BRCA2 Alleles and Variant-Specific Drug ScreeningNovelty: A functional assay to identify genetic variants of tumor suppressor genes that may be associated with cancer risk, applicable for personalized therapy and genome-specific drug screening.Value Proposition: The formation of human cancers is often associated...

Published: 9/26/2024 | Inventor(s): Eike Gallmeier, Thomas Hucl, Scott Kern

Keywords(s): Assay, Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Diagnostic Biomarkers

A Fast, Cell-based, High-throughput Assay for the Identification of Compounds with DNA-interstrand Crosslinking Capability

C04868: A Fast, Cell-based, High-throughput Assay for the Identification of Compounds with DNA-interstrand Crosslinking Capability Technical Details: Using somatic cell gene targeting, isogenic cell clones were created from the colorectal cancer cell line RKO. Each KO cell line differed only in the allelic status of one Fanconi Anemia (FA) gene,...

Published: 9/26/2024 | Inventor(s): Eike Gallmeier, Scott Kern

Keywords(s): Cloning Reagents, Discovery/Research Tools, Oncogene, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

Identification of P53-activating Compounds for Cancer Research and Therapy

C03857: Cell line to identify inhibitors of p53 Technical Details: An exciting, new invention from the laboratory of Dr. Scott Kern at The Johns Hopkins University School of Medicine for the identification of p53 activating compounds that would be of interest to In Vitro Technologies. The status of p53 varies among human tumors and has been associated...

Published: 9/26/2024 | Inventor(s): Taylor Riall, Scott Kern

Keywords(s): Basic Research Biomarker, Biomarker, Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, Oncogene, Pharmakodynamic Biomarker, Research Reagent, Single, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

Facilitation of the Expression in Eukaryotic Cells of Exogenous Genes by an Exogenous Compound

C03611: Facilitation of the Expression in Eukaryotic Cells of Exogenous Genes by an Exogenous Compound Technical Details: Scriptaid is a histone deacetylase inhibitor that provides a simple means of increasing the efficiency of plasmid-based reporter and expression constructs. When added to mammalian cells in culture Scriptaid confers a 10 to 15-fold...

Published: 9/26/2024 | Inventor(s): Gloria Su, Scott Kern

Keywords(s): Antagonists/Inhibitors, Discovery/Research Tools, In Vitro Research Tool, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Vectors & Plasmids