Search Results - kathleen+burns

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Unmet NeedIn the United States, approximately 1.9-million new cancer cases are projected to be diagnosed with 608,570 cancer deaths in 2021 (see ACS). Early screening initiatives that detect cancer as well as novel therapeutics that target and destroy tumor cells may lead to a future decrease in the number of cancer-related mortality. To improve the...

Published: 7/5/2024 | Inventor(s): Kathleen Burns, Andrew Holland, Daniel Ardeljan

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology

Enhancing Translation of LINE-1 Encoded ORF2p for Cancer Therapeutics

Unmet NeedA substantial portion (~50%) of human malignancies overexpress a protein encoded by a genomic repeat, the Long INterspersed Element-1 (LINE-1)-encoded ORF1p. These include colon, pancreatic, lung, ovarian, breast and prostate cancers. LINE-1 is a retrotransposon that codes for both RNA and proteins which in turn function to make more genomic...

Published: 7/5/2024 | Inventor(s): Kathleen Burns

Keywords(s): Cancers, Disease Indication, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Gene Therapies

A Mouse Monoclonal Antibody Against Human LINE-1 ORF1p

Invention Novelty:Johns Hopkins researchers have developed a monoclonal antibody against the cancer-associated protein LINE-1 ORF1p. Technical Overview:There is great unmet need for a method of easily and broadly screening for cancer. Biomarkers, one of the major tools used in cancer screening, are usually specific for one cancer type, making testing...

Published: 7/4/2024 | Inventor(s): Kathleen Burns, Jef Boeke, Nemanja Rodic, Martin Taylor

Keywords(s): Antibodies, Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, Monoclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools