Search Results - in+silico+research+tool

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A Supervised Methodology for Predictive Signatures in Cancer Etiology

Unmet NeedThere are more than 600,000 annual cancer deaths in the United States. One of the biggest hurdles in combatting and curing different types of cancer is understanding the etiology of cancer. Cancer is the end-result of a process of accumulation of driver epigenetic mutations and other events. It is well-known that some of these driver mutations...

Published: 6/27/2024 | Inventor(s): Cristian Tomasetti, Bahman Afsari

Keywords(s): Cancers, Clinical Diagnostics, Computational Medicine, Computational Modeling Tool, Copyright, Discovery/Research Tools, Disease Indication, In Silico Research Tool, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Copyright

Simulation and Database-guided Antimicrobial Peptide Evolution

Unmet Need Antimicrobial peptides (AMPs) are typically amphiphilic peptides that have selectively to target and kill bacteria at low micromolar concentrations, often without harming mammalian cells and are thus an excellent candidate for drug development.Technology OverviewThe new methodology combines molecular dynamic simulations and database-guided...

Published: 6/27/2024 | Inventor(s): Charles Chen, Martin Ulmschneider

Keywords(s): Computational Modeling Tool, Discovery/Research Tools, In Silico Research Tool, In Vitro Research Tool, Peptides, Recombinant Proteins, Research Instrument, Research Reagent

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Computers, Electronics & Software

ADPriboDB: A database of ADP-ribosylated proteins

Unmet NeedPharmaceutical companies are conducting clinical trials for PARP inhibitors to treat cancer patients. There is currently only one drug approved in this class, but there is a need for continued and improved knowledge of PARP substrates. Technology OverviewJHU researchers created a database that curates the last 30 years of literature on ADP-ribosylation...

Published: 6/27/2024 | Inventor(s): Anthony Leung

Keywords(s): Antagonists/Inhibitors, Cancers, Database, Discovery/Research Tools, Disease Indication, In Silico Research Tool, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Research Tools, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules

Compute Align

A newly invented DNA alignment algorithm combined and fine tuned with recent advances in GPU technology resulted in a 40x 50 x speed increase and better quality results. Bundled with appropriate HW+SW environment, one Compute Align appliance is expected to provide the same speed of data processing capability as the highest speed input data provider,...

Published: 6/27/2024 | Inventor(s): Richard Wilton, Tamas Budavari, Benjamin Langmead, Steven Salzberg, Sandor Szalay

Keywords(s): Computing; Calculating; Counting, Discovery/Research Tools, Electrical Digital Data Processing, In Silico Research Tool, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools > Bioinformatics

A method for computationally predicting electrically optimal placement sites for internal defibrillators in pediatric and congenital heart disease patients

C12529: Method to Predict Optimal ICD PlacementNovelty: A method for computationally predicting electrically optimal placement sites for implantable cardioverter- defibrillators (ICDs), specifically in pediatric and congenital heart defect patients.Value Proposition: Standard procedures for implantation of ICDs typically cannot be used in pediatric...

Published: 6/27/2024 | Inventor(s): Fijoy Vadakkumpadan, Lukas Rantner, Natalia Trayanova

Keywords(s): Atrial Fibrillation (AF), Cardiovascular Diseases, Computational Modeling Tool, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, Disease Indication, In Silico Research Tool, Physics, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Cardiovascular > Atrial Fibrillation, Technology Classifications > Medical Devices > Cardiology, Technology Classifications > Computers, Electronics & Software > Algorithms

Mutation Position Imaging Toolbox (muPIT) Interactive: Webserver for mapping variant positions to annotated, interactive 3D structures

C12199: Mutation Position Imaging Toolbox (muPIT) InteractiveNovelty: The current invention is a browser-based application for single nucleotide variants and mutations, designed to map genomic positions onto 3D protein structures.Value Proposition: The vast amount of available sequencing data is evidence that the limiting factor of research is shifting...

Published: 6/27/2024 | Inventor(s): Rick Kim, Mark Diekhans, Michael Ryan, Rachel Karchin, Dewey Kim

Keywords(s): Computational Modeling Tool, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, Electrical Digital Data Processing, In Silico Research Tool, Nanoscale Modeling, Physics

A computational approach for generating representative hepatitis C virus genomic sequences

C11517: Novel Synthetic Genomic Reconstruct for HCV TherapeuticsNovelty: This technology is an optimized synthetic reconstruct of genotype 1a hepatitis C virus (HCV) that is representative of globally-circulating strains of HCVValue Proposition: The reconstructed HCV genotype 1a virus is highly functional without adaptive mutations, which allows it...

Published: 6/27/2024 | Inventor(s): Supriya Munshaw, Lin Liu, Stuart Ray

Keywords(s): Computational Modeling Tool, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, Disease Indication, Hepatitis C Virus (HCV), In Silico Research Tool, Infectious Diseases, Physics

Category(s): Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus (HCV), Technology Classifications > Research Tools

An Algorithm for the Discovery of Robust Protein Biomarkers with Application to the Design of Classification Protein Arrays

C04758: An Algorithm for the Discovery of Robust Protein Biomarkers with Application to the Design of Classification Protein ArraysNovelty: The current invention is a general, quantitative method for the selection of protein biomarkers supporting accurate, sensitive and specific classification of protein profiles.Value Proposition: Biomarker discovery...

Published: 6/27/2024 | Inventor(s): Donald Geman, Daniel Naiman, Troy Anderson, Aik Choon Tan, Raimond Winslow

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Research Tools

Human Protein Reference Database

C04236: Human Protein Reference Database Technical Details: The present invention is a Human Protein Reference Database (HPRD), a database of unique human proteins that includes almost all proteins known to be involved in human diseases. This database includes detailed features of each of the proteins depicted in a user friendly and graphic manner....

Published: 6/27/2024 | Inventor(s): Krishna Deshpande, Akhilesh Pandey

Keywords(s): Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Database, Discovery/Research Tools, In Silico Research Tool, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

The Cardiac Ausculatory Recording Database (CARD): an Internet-based software Program and Digital Heart Sound Recording Database for Teaching and Study of Cardiac Auscultation

C03810: The Cardiac Ausculatory Recording Database (CARD): an Internet-based software Program and Digital Heart Sound Recording Database for Teaching and Study of Cardiac Auscultation Technical Details: The Cardiac Auscultatory Recording Database (CARD) was also developed. Developed using the Microsoft Access relational database program, CARD is...

Published: 6/27/2024 | Inventor(s): Charles Tuchinda, Lisa Blodgett, William Thompson

Keywords(s): Cardiovascular Diseases, Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Database, Discovery/Research Tools, Disease Indication, In Silico Research Tool, Physics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Databases

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