Search Results - computer+systems+based+on+biological+models

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Comprehensive Phenotyping Reveals Robust Determination to Cellular Biological Age

Technology OverviewJHU researchers have developed a platform to determine the cellular biological age of individuals based on quantifiable functional outputs of their cells. Using a comprehensive approach, of high-throughput single cell technologies to measure biochemical and biophysical properties of cells, we have further developed a generalized linear...

Published: 3/13/2025 | Inventor(s): Jude Phillip, Denis Wirtz, Pei-Hsun Wu, Jeremy Walston

Keywords(s): Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, In Vitro Research Tool, Physics, Research Instrument

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools

Using Patient-Specific Modeling of the Heart for Risk Stratification for Ventricular Arrhythmia in Patients with Repaired Tetralogy of Fallot (TOF) via Image-Based Computational Simulations

The JHU inventors previous invention (C11304) provides a non-invasive method to identify the optimal ablation sites for infarct-related ventricular tachycardia (VT) by using 3D electrophysiological heart simulations with a model reconstructed from the patient’s late gadolinium-enhanced (LGE) MRI image. In this application, the inventors extend that...

Published: 3/13/2025 | Inventor(s): Natalia Trayanova, Adityo Prakosa, Mark Cartoski, Patrick Boyle

Keywords(s): Arrhythmias, Cardiovascular Diseases, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Disease Indication, Physics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Arrhythmias, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Cardiovascular

SNVBox – UPDATE

Unmet Need In the new “post-genome” era of personalized medicine, many variants critical to disease susceptibilities and drug sensitivities will be identified and increased numbers of people will undergo genetic testing. The Karchin group is developing algorithms and tools to facilitate this process. These models are being applied to cancer genomics,...

Published: 3/13/2025 | Inventor(s): Rachel Karchin, Michael Ryan, Mark Diekhans, Hannah Carter, Christopher Douville, Rick Kim

Keywords(s): Computer and Network Systems, Computer Software, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computer Systems Utilizing Knowledge Based Models, Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Electrical Digital Data Processing, Physics

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software > Algorithms

A Novel methodology for arrhythmia risk stratification by assessing qt interval instability

Clinical studies have demonstrated that beat-to-beat instability in QT interval, which is the global manifestation of instability in ventricular repolarization dynamics, predicts propensity to arrhythmias. However, a robust methodology to assess QT interval instability and thus predict propensity to arrhythmia in a patient-specific manner is currently...

Published: 3/13/2025 | Inventor(s): Xiaozhong Chen, Natalia Trayanova

Keywords(s): Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Physics

Category(s): Technology Classifications > Computers, Electronics & Software

A Dose-rate Method For Prescribing Radioiodine Treatment In Thyroid Cancer Patients With Lung Metastases

UNMET NEED Radiopharmaceutical therapy (RPT) is an emerging cancer treatment modality in which tumor-targeting molecules are used to deliver radioactive atoms thereby irradiating tumors preferentially over normal organs. Therefore, precision medicine dosimetry is required so that patients are administered the appropriate amount of the RPT for safe...

Published: 3/13/2025 | Inventor(s): George Sgouros, Robert Hobbs, Andrew Prideaux, Hong Song

Keywords(s): Cancers, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Disease Indication, Physics, Thyroid Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Endocrinology, Clinical and Disease Specializations > Oncology > Thyroid Cancer, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Oncology

Prediction of Targets for Catheter Ablation of Persistent Atrial Fibrillation based on Analysis of Patient-specific Fibrosis Patterns

Novel Technique to Identify Ablation Targets in Atrial Fibrillation Patients With FibrosisJHU REF: C13278Invention novelty: A method to identify a set of potential atrial fibrillation (AF) ablation targets, in real time, by analyzing the personalized spatial distribution of atrial fibrosis.Value Proposition:Catheter-based ablation to terminate atrial...

Published: 3/13/2025 | Inventor(s): Patrick Boyle, Sohail Zahid, Natalia Trayanova

Keywords(s): Atrial Fibrillation, Atrial Fibrillation (AF), Cardiovascular Diseases, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Disease Indication, Integrated Imaging System, Interventional and Surgical Systems, Physics, Surgical Navigation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Atrial Fibrillation, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgical, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices

4D Digital Mouse Whole Body (MOBY) Phantom

C04403: 4D Digital Mouse Whole Body (MOBY) PhantomNovelty: The 4D digital mouse whole body (MOBY) phantom is a realistic and flexible model of the mouse anatomy and cardiac and respiratory motions for use in molecular imaging research.Value Proposition: Currently, there is a lack of realistic computer generated phantoms modeling the mouse anatomy and...

Published: 3/13/2025 | Inventor(s): Benjamin Tsui, William Segars

Keywords(s): Animal Imaging Tools, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, In Vivo Research Tool, Physics

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools

A method for computationally predicting electrically optimal placement sites for internal defibrillators in pediatric and congenital heart disease patients

C12529: Method to Predict Optimal ICD PlacementNovelty: A method for computationally predicting electrically optimal placement sites for implantable cardioverter- defibrillators (ICDs), specifically in pediatric and congenital heart defect patients.Value Proposition: Standard procedures for implantation of ICDs typically cannot be used in pediatric...

Published: 3/13/2025 | Inventor(s): Fijoy Vadakkumpadan, Lukas Rantner, Natalia Trayanova

Keywords(s): Atrial Fibrillation (AF), Cardiovascular Diseases, Computational Modeling Tool, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, Disease Indication, In Silico Research Tool, Physics, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Cardiovascular > Atrial Fibrillation, Technology Classifications > Medical Devices > Cardiology, Technology Classifications > Computers, Electronics & Software > Algorithms

Mutation Position Imaging Toolbox (muPIT) Interactive: Webserver for mapping variant positions to annotated, interactive 3D structures

C12199: Mutation Position Imaging Toolbox (muPIT) InteractiveNovelty: The current invention is a browser-based application for single nucleotide variants and mutations, designed to map genomic positions onto 3D protein structures.Value Proposition: The vast amount of available sequencing data is evidence that the limiting factor of research is shifting...

Published: 3/13/2025 | Inventor(s): Rick Kim, Mark Diekhans, Michael Ryan, Rachel Karchin, Dewey Kim

Keywords(s): Computational Modeling Tool, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, Electrical Digital Data Processing, In Silico Research Tool, Nanoscale Modeling, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools

A computational approach for generating representative hepatitis C virus genomic sequences

C11517: Novel Synthetic Genomic Reconstruct for HCV TherapeuticsNovelty: This technology is an optimized synthetic reconstruct of genotype 1a hepatitis C virus (HCV) that is representative of globally-circulating strains of HCVValue Proposition: The reconstructed HCV genotype 1a virus is highly functional without adaptive mutations, which allows it...

Published: 3/13/2025 | Inventor(s): Supriya Munshaw, Lin Liu, Stuart Ray

Keywords(s): Computational Modeling Tool, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, Disease Indication, Hepatitis C Virus (HCV), In Silico Research Tool, Infectious Diseases, Physics

Category(s): Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus (HCV), Technology Classifications > Research Tools

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