Search Results - leslie+tung

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Grid of Responses Indicating Drug Sensitivity

Unmet NeedDrug development is a long and costly process characterized by a high degree of attrition. Cardiotoxicity is the most common reason for withdrawing candidate drugs from the development pipeline, with 30% of drugs withdrawn during the clinical development phase. Improvements in methodologies for assessing drug cardiotoxicity during preclinical...

Published: 3/14/2025 | Inventor(s): Leslie Tung, Adriana Blazeski

Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics (Old), In Vitro Research Tool, Research Instrument

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays

Engineered Heart Slices

Engineered Heart SliceJHU REF: C12744Invention Novelty: A novel method of producing acellular cardiac tissue scaffolds with stem-cells for tissue regeneration productsValue Proposition: Tissue constructs using cardiac cells and a base matrix have been developed in the past, and several methods of creating these constructs have been described. However...

Published: 3/13/2025 | Inventor(s): Adriana Blazeski, Leslie Tung

Keywords(s): Basic Research Biomarker, Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools, Clinical and Disease Specializations > Cardiovascular

Method for Termination of Cardiac Fibrillation and Tachycardia

C10844: Gentler Method for Termination of Cardiac ArrhythmiasNovelty: A method to prevent cardiac sudden death by delivering a high frequency current or electric field to the myocardium, with less associated damage to the heart.Value Proposition: Currently the only reliable way to terminate fibrillation is by delivering a high voltage DC shock to cause...

Published: 3/13/2025 | Inventor(s): Harikrishna Tandri, Ronald Berger, Leslie Tung, Henry Halperin, David Hunter, Seth Weinberg

Keywords(s): Arrhythmias, Cardiovascular Diseases, Disease Indication, Electrical Stimulation Device, Implanted Device, Implants, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Arrhythmias, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices