Search Results - tza-huei+wang

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Digital High Resolution Melt Microfluidic Platform and Assay for Assessing Locus-specific Molecular Heterogeneity of DNA Methylation

Value Proposition· Simple, low-cost microfluidic tool that evaluates DNA methylation using non-invasive liquid biopsy samples. · Allows for sensitive, specific evaluation of epigenetic biomarkers for early detection of cancer. · Includes software and algorithms for improved diagnostic interpretation of DNA methylation analyses. Unmet...

Published: 6/28/2024 | Inventor(s): Tza-Huei Wang, Christine O'Keefe, Thomas Pisanic

Keywords(s):

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Blood & Tissue Samples

Methods for Payload and Size Characterization of Nucleic Acid Nanoparticles

Polymeric and lipid nanoparticles (NPs) are an effective and safe method for therapeutic delivery. At each of the various steps in nanoparticle development and manufacturing (i.e., research and design, quality assurance), assessing the features of these vehicles is essential. Some features (i.e., packaging characteristics, cargo location, structure...

Published: 6/28/2024 | Inventor(s): Tza-Huei Wang, Hai-Quan Mao, Sixuan Li, Yizong Hu, Andrew Li

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids

Simultaneous Droplet-based Genotyping and mRNA Capture of Single Cells

Unmet Need / Invention Novelty: Single cell RNA transcriptomics has become an important technology in research and diagnostics but can be improved by incorporating genomic readouts from the same cells whose transcriptomes are being analyzed. Sequencing both genomic DNA and messenger RNA from a single cell is crucial for associating a cell’s genotype...

Published: 6/28/2024 | Inventor(s): Donald Zack, Claire Bell, Tza-Huei Wang, Aniruddha Kaushik, Pengfei Zhang

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays

Methods for Reagent Storage and Stabilization within an Automated Assay Scaffold

Unmet Need / Invention Novelty: On-demand magnetofluidic cartridges containing pre-loaded assay reagents present a low-cost, simple point-of care diagnostic solution. However, current technology lacks provisions for prolonged shelf-life at ambient temperatures and stable transport without leakage of the pre-loaded reagents. Technical Details: Researchers...

Published: 6/28/2024 | Inventor(s): Tza-Huei Wang, Alexander Trick, Fan-En Chen

Keywords(s):

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Engineering Tech > Materials

Method for Genetic Analysis of Plant Materials in Remote Testing Sites

Unmet NeedThe study of plant genetics has immense economic impacts as many crops are genetically modified to increase yields or provide resistance to herbicides and diseases. Because of these changes, many genetically modified crops have been heralded as having great potential in developing countries. Even in the United States today, approximately 92%...

Published: 6/27/2024 | Inventor(s): Tza-Huei Wang, Dong Shin, Fan-En Chen, Yue Yun

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Research Instrument, Research Reagent

Category(s): Technology Classifications > Research Tools > Specimen Handling, Technology Classifications > Engineering Tech > Agriculture

Quantitative Measurements of 16S rRNA from Single Bacterial Cells for Accelerated Pathogen Identification and Antimicrobial Susceptibility Testing

Unmet needUrinary tract infection (UTI) is one of the most common infectious diseases in the world, affecting 50-60% of women at least once in their lifetime. In the United States, UTIs account for over 2 million emergency department visits and approximately $3.5 billion in healthcare costs annually. Unfortunately, UTI resistance to first line antibiotics...

Published: 6/28/2024 | Inventor(s): Tza-Huei Wang, Aniruddha Kaushik, Kuangwen Hsieh

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Antimicrobial Resistance

miRNA Analysis Method

#C11885: miRNA Analysis MethodUnmet NeedThe gold standard for miRNA profiling is quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). While qRT-PCR is fast, reproducible, and can handle smaller input samples than other profiling methods (Chugh et al.), it can only evaluate less than 10 miRNAs at a time. Other methods can profile thousands...

Published: 6/27/2024 | Inventor(s): Yunke Song, Kelvin Liu, Tza-Huei Wang

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

A Disposable Reagent Scaffold for Biochemical Process Integration

Unmet NeedIn 2017, there were 1.7 million cases of chlamydial infection reported within the United States. Sixty-five percent of the chlamydia diagnoses were within the ages 15-24, and though CDC recommends annual chlamydia screen for sexually active women within these ages, less than half of eligible women are screen according to these guidelines....

Published: 6/27/2024 | Inventor(s): Tza-Huei Wang, Dong Shin, Alexander Trick

Keywords(s):

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays

Impedance Based Feedback Control of Microfluidic Valves

Unmet NeedDroplet microfluidics is a growing field due to its potential to create high throughput assays while reducing reagent consumption in the process. The technology creates small droplets within fluid channels to generate biological assays. Frequently, these assays require an injection step so as to merge a reagent with the droplet at the correct...

Published: 6/27/2024 | Inventor(s): Tza-Huei Wang, Brant Axt, Yi-Fan Hsieh, Kuangwen Hsieh, Helena Zec, Aniruddha Kaushik, Yue Yun

Keywords(s): Computer and Network Systems, Computer Software, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools

Multiplexed, Continuous-Flow, Droplet-Based Platform for High-Throughput Genetic Detection

Unmet NeedMaintaining levels of crop production has become increasingly critical amidst growing populations and other emerging challenges for the $300 billion global crop market. Traditional crossbreeding of plants for desirable phenotypic traits is being improved by genetic marker assisted selection (MAS), where known genetic markers associated with...

Published: 6/27/2024 | Inventor(s): Tza-Huei Wang, Kuangwen Hsieh, Helena Zec, Lingshu Liu, Aniruddha Kaushik, Yue Yun

Keywords(s): Assay, Clinical Diagnostics, Crop Management, In Vitro Diagnostics, Microfluidic, Operations Management

Category(s): Technology Classifications > Industrial Tech > Agriculture, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Diagnostics, Technology Classifications > Industrial Tech, Technology Classifications > Research Tools, Technology Classifications > Engineering Tech > Agriculture

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